Research Use Only. KIRhub outputs are computational research artifacts. They are not validated for clinical decision-making, diagnosis, or treatment.
KIRhub 2.0· v2
Ependymoma Hub
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Knowledge graph explorer

A typed graph of drugs, kinases, substrates, pathways, variants and cohorts. Edge color encodes how each link is known — measured, derived, modeled or external.
How to use the Map tab

The graph-of-the-graph: every entity type and how the types connect, colored by how each link is known (measured / derived / modeled / external).

  • Click an entity-type card to browse its instances in Focus.
  • Click a relationship row to drill into those specific edges.
  • Click a node or type chip to isolate just that type's relationships.
  • Toggle the provenance legend to filter by evidence kind.

💡 Start here to learn what the graph contains before diving in.

The graph-of-the-graph. Nodes are entity types; edges are type-level relationships colored by how they’re known. Click a type or a row to explore those instances.

Relationship map

Isolate a type’s relationships:
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Click a node or a type chip to isolate its relationships. Open an entity type below to explore its instances.

Entity types

Relationship types

SubjectRelationshipObjectInstances ▼ⓘProvenanceⓘSources ⓘStatusⓘ
sampledysregulated_inpathway70,590● derivedkirhub.gsvalive
drugreversessample43,341● modeledkirhub.pi_scorerlive
kinasedrivessample26,311● modeledkirhub.pi_scorerlive
samplebelongs_tocohort14,118● measuredkirhub.oncoscapelive
samplehas_cancer_typecancer14,118● measuredkirhub.oncoscapelive
kinasephosphorylatesgene10,605● externaloperator_t.omnipathlive
genephosphorylatesgene6,583● externaloperator_t.omnipathlive
druginhibitsvariant3,604● measuredkirhub.measurementslive
genemember_ofpathway3,296● externalkirhub.kinase_mesenchymal_program, msigdb.hallmarklive
kinasephosphorylateskinase1,490● externaloperator_t.omnipathlive
genephosphorylateskinase1,487● externaloperator_t.omnipathlive
druginhibitskinase1,281● measuredkirhub.measurementslive
drugreversespathway903● modeledkirhub.pi_scorerlive
druginhibitsgene724● measuredkirhub.measurementslive
genedrivessample533● modeledkirhub.pi_scorerlive
kinasemutated_incancer448● externalkirhub.mutation_cancerlive
kinasehas_structurestructure384● externalalphafoldlive
kinasemember_ofpathway301● externalkirhub.kinase_mesenchymal_program, msigdb.hallmarklive
variantvariant_ofkinase274● derivedkirhub.variantslive
drugreversescohort180● modeledkirhub.cohort_consensuslive
genemutated_incancer94● externalkirhub.mutation_cancerlive
kinaseparalog_ofkinase39● derivedkirhub.paralog_groupslive
geneparalog_ofgene10● derivedkirhub.paralog_groupslive
geneparalog_ofkinase8● derivedkirhub.paralog_groupslive
kinaseparalog_ofgene6● derivedkirhub.paralog_groupslive
kinaseessential_incancer—● externaldepmapplanned
drugin_trial_forcancer—● externalclinicaltrials.govplanned

Provenance: Measured (assay) · Derived (computed) · Modeled (scorer) · External (DB / lit). “planned” rows are modeled in the schema but not yet materialized.

What do these mean? (relationships & provenance)

Provenance — how a link is known

Measured (assay)
Directly measured in a KIRhub kinase-inhibition assay.
Derived (computed)
Computed from our own data without a model (e.g. paralogy, variant parsing).
Modeled (scorer)
Output of a scoring model — the pathway-reversal scorer (Π = D·T·P).
External (DB / lit)
Imported from an external knowledge base or the literature.

Relationships

inhibits
Assay-measured inhibition of a kinase/variant by a drug (kept at ≥80% at 1 µM). Confidence = inhibition %.
phosphorylates
Kinase phosphorylates a substrate — OmniPath (curated) or NetworKIN (predicted).
member_of
Gene is a member of this pathway's gene set (MSigDB Hallmark/Reactome/KEGG).
reverses
Drug's modeled perturbation of a pathway / cohort pathway-state (Π = D·T·P). Confidence = normalized Π.
mutated_in
Gene is recurrently mutated in this cancer (literature-curated, KIRhub supplementary table).
paralog_of
Genes are paralogs (same family) — flags resistance/redundancy candidates.
interacts_with
Protein–protein interaction from STRING (text-mined or predicted channel).
variant_of
Variant is a sequence variant of this gene.
has_structure
Gene has a 3D structure — an AlphaFold model exists for its UniProt accession.
belongs_to
Tumor sample belongs to this cohort.
has_cancer_type
Tumor sample is annotated with this cancer type.
dysregulated_in
Pathway is dysregulated in this sample — top Hallmark pathways by |GSVA| enrichment (sample-specific). Confidence = |GSVA|; attrs note up/down.
drives
Driver kinase attributed to this sample's top predicted-reversal drugs (primary_driver_kinases). A direct sample↔kinase link; modeled.
essential_in
Gene is a CRISPR dependency in this cancer (DepMap). Planned — needs DepMap gene-effect data.
in_trial_for
Drug is in a clinical trial for this cancer (ClinicalTrials.gov). Planned — needs a connected build.