From a patient mutation to a ranked drug list.

Drop in a VCF, MAF, or variant list. Three-tier matching, PHI scanned, nothing persists.

Try a sample match Browse the variant atlas

Clinical kinase inhibitors

384

Kinases profiled (WT)

200

Annotated variants

Cancer lineages

Clinical workflows

Built for the moment a clinician needs an answer about a specific patient or trial.

Patient Mutation Matcher

Upload a VCF, MAF, or variant list and get tier-ranked drug candidates per mutation. PHI-detection guardrail; nothing persists.

Run a match

Clinical Trial Linker

Live ClinicalTrials.gov search for any drug, kinase, or mutation — with phase, status, and enrollment timelines surfaced.

Search trials

Dose-response curves

Hill-fit IC₅₀ + slope across every profiled drug × kinase pair, with extrapolation flags for partial inhibition.

View curves

Comparative analytics

Side-by-side comparison and discovery across the inhibitor landscape.

⇄

Compare drugs

Heatmap up to six drugs across any target panel; ranks targets by maximum inhibition.

Open comparator

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Repurposing opportunities

Score off-label drug–kinase pairs by selectivity-adjusted inhibition; sort and filter.

See candidates

⌬

Polypharmacology network

Threshold-tunable drug ↔ kinase bipartite graph. Useful for spotting hub kinases and overlap.

Open graph

⊕

Combination recommender

Pick a target set; get drug pairs ranked by coverage minus off-target overlap.

Build combos

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EMT volcano

Differential kinase expression between epithelial and mesenchymal states, with highlight links.

View volcano

∇

Variant atlas

Browse the annotated variant catalog. Each variant links to drug activity on-variant vs. wild-type.

Browse variants

Polypharmacology landscape

Every drug placed by promiscuity (x) vs. selectivity (y). Click any point to open the drug profile.

How to read: x is the drug's mean inhibition across all profiled kinases at 1 μM — right means it hits more of the kinome harder. y is the Gini coefficient of that inhibition vector — high means the activity is concentrated on a small number of targets (selective); low means it spreads its activity across many kinases. Dotted lines mark the dataset means; marker color repeats x for a quick visual sort. Hover any drug to see exact values; click to open its profile.