KIRhub Platform · v0.1.092 inhibitors×384 kinasesResearch only

Clinical genomics · oncology

From a patient mutation to a ranked drug list.

Drop in a VCF, MAF, or variant list. Three-tier matching, PHI scanned, nothing persists.

Try a sample match Browse the variant atlas

Clinical kinase inhibitors

384

Kinases profiled (WT)

200

Annotated variants

Cancer lineages

Clinical workflows

Built for the moment a clinician needs an answer about a specific patient or trial.

Patient Mutation Matcher

Upload a VCF, MAF, or variant list and get tier-ranked drug candidates per mutation. PHI-detection guardrail; nothing persists.

Run a match

Clinical Trial Linker

Live ClinicalTrials.gov search for any drug, kinase, or mutation — with phase, status, and enrollment timelines surfaced.

Search trials

Dose-response curves

Hill-fit IC₅₀ + slope across every profiled drug × kinase pair, with extrapolation flags for partial inhibition.

View curves

Comparative analytics

Side-by-side comparison and discovery across the inhibitor landscape.

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Compare drugs

Heatmap up to six drugs across any target panel; ranks targets by maximum inhibition.

Open comparator

↻

Repurposing opportunities

Score off-label drug–kinase pairs by selectivity-adjusted inhibition; sort and filter.

See candidates

⌬

Polypharmacology network

Threshold-tunable drug ↔ kinase bipartite graph. Useful for spotting hub kinases and overlap.

Open graph

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Combination recommender

Pick a target set; get drug pairs ranked by coverage minus off-target overlap.

Build combos

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EMT volcano

Differential kinase expression between epithelial and mesenchymal states, with highlight links.

View volcano

∇

Variant atlas

Browse the annotated variant catalog. Each variant links to drug activity on-variant vs. wild-type.

Browse variants

Pathway reversal — single sample

For one tumor sample, rank approved kinase inhibitors by predicted ability to reverse its pathway state. Heatmap + polypharmacology network show which kinases drive the score.

Open workbench

Σ̄

Pathway reversal — cohort

Aggregate the scorer across every sample in a cohort (project + facet filter). Returns median drug ranking with IQR and positive-fraction across the cohort.

Score a cohort

Pathway reversal — compare

Two cohorts side-by-side. Drugs ranked by Δ-reversal-score identify candidates that selectively reverse one cohort's biology but not the other's.

Compare cohorts

✱

11 cross-linked discoveries built from the joint geometry of 9,200 tumors and 92 drugs in pathway space. Tumor maps, drug perturbation maps, pathway co-activation, drug deserts, the orphan-ideal search, and more — all reachable from any drug or sample in the platform.

Open the atlas

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Oncoscape cohorts

Browse the ingested multi-omics tumor cohorts. Drill into any sample's GSVA pathway state and score it with the reversal workbench.

Browse cohorts

Polypharmacology landscape

Every drug placed by promiscuity (x) vs. selectivity (y). Click any point to open the drug profile.

MeasuredDerived

How to read: x is the drug's mean inhibition across all profiled kinases at 1 μM — right means it hits more of the kinome harder. y is the Gini coefficient of that inhibition vector — high means the activity is concentrated on a small number of targets (selective); low means it spreads its activity across many kinases. Dotted lines mark the dataset means; marker color repeats x for a quick visual sort. Hover any drug to see exact values; click to open its profile.