Pick your role
Tools and shortcuts tailored to your work.
🧪 Kinase & drug catalog
Compare selectivity across the kinome. Pick any kinase to see which drugs hit it hardest, on-target vs off-target, and known resistance variants. Drill into calibrated drugs and the pathway graph.
Other Advanced tools
Deep-dive workbenches/tools, curated for the researcher persona. These open in a new tab.
Repurposing
Find drugs whose realized polypharmacology hits off-label kinases — a real repurposing signal.
Combinations
Recommend drug combinations that cover a target-kinase set above an inhibition threshold.
Polypharm network
Bipartite drug-kinase graph filtered by inhibition threshold — see promiscuity at a glance.
Compare drugs
Side-by-side heatmap and head-to-head scatter for any set of drugs across a kinase set.
Dose-response
10-dose IC50 curves for 14 clinical kinase inhibitors across 369 kinases.
EMT volcano
Differential kinase expression between epithelial and mesenchymal samples on a volcano plot.
EMT druggability
Which inhibitors hit the 47 mesenchymal-specific kinases (Table S9), expression-weighted, with a measured-vs-inferred reversal cross-validation.
Mesenchymal Reversal Workbench
Combination designer (set-cover over the 47-kinase program), resistance-aware targeting, per-sample EMT reversal across the tumor atlas, and a confidence shortlist.
Atlas combinations
Atlas view of combination opportunities across the polypharmacology landscape.
Drug map
Atlas-wide map of the drug catalog projected onto the kinase landscape.
Cohort reversal
Pathway-reversal scoring run across an entire cohort with per-sample provenance.
Compare reversal
Compare pathway-reversal scores between cohorts, libraries, or operator sets.
Joint map
Joint kinase/drug embedding with all provenance and correlation overlays.
Entropy atlas
Entropy/redundancy measures across the polypharmacology graph.
Pathway graph
Operator pathway graph with edge counts, signs, and library provenance.
Modules
Workbench modules: WT/mutant drug discovery and lineage essentiality.
Oncoscape cohorts
Browse all ingested Oncoscape multi-omics cohorts with sample-level drill-down.
Lineages
DepMap-derived cancer lineage index with essential-kinase counts.
Variants
Catalog of profiled variants with HGVS, residue, and tier metadata.
Global search
Cross-entity search across drugs, kinases, variants, and lineages.
Advanced — calibration & data provenance
Pathway-library calibration counts and the full versioned cohort catalog. Surface when you need to audit data provenance or pin a model release.
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# Cohorts
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# Samples
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# Drugs
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Calibrated %