Research Use Only. KIRhub outputs are computational research artifacts. They are not validated for clinical decision-making, diagnosis, or treatment.

← The Pathway Atlas

The pathway co-activation graph

Derived

Across all 9,200 tumors, every pair of Hallmark pathways correlated. Edges shown at |r| ≥ 0.40. Red = positive (move together); blue = negative (anticorrelated).

ADIPOGENESISALLOGRAFT_REJECTIOANDROGEN_RESPONSEANGIOGENESISAPICAL_JUNCTIONAPICAL_SURFACEAPOPTOSISBILE_ACID_METABOLICHOLESTEROL_HOMEOSCOAGULATIONCOMPLEMENTDNA_REPAIRE2F_TARGETSEPITHELIAL_MESENCHESTROGEN_RESPONSE_ESTROGEN_RESPONSE_FATTY_ACID_METABOLG2M_CHECKPOINTGLYCOLYSISHEDGEHOG_SIGNALINGHEME_METABOLISMHYPOXIAIL2_STAT5_SIGNALINIL6_JAK_STAT3_SIGNINFLAMMATORY_RESPOINTERFERON_ALPHA_RINTERFERON_GAMMA_RKRAS_SIGNALING_DNKRAS_SIGNALING_UPMITOTIC_SPINDLEMTORC1_SIGNALINGMYC_TARGETS_V1MYC_TARGETS_V2MYOGENESISNOTCH_SIGNALINGOXIDATIVE_PHOSPHORP53_PATHWAYPANCREAS_BETA_CELLPEROXISOMEPI3K_AKT_MTOR_SIGNPROTEIN_SECRETIONREACTIVE_OXYGEN_SPSPERMATOGENESISTGF_BETA_SIGNALINGTNFA_SIGNALING_VIAUNFOLDED_PROTEIN_RUV_RESPONSE_DNUV_RESPONSE_UPWNT_BETA_CATENIN_SXENOBIOTIC_METABOL
50 pathways · 374 edges at |r| ≥ 0.4

Strongest co-activations

Derived

Top positive correlations.

  • E2F_TARGETS↔G2M_CHECKPOINTr = +0.97
  • INTERFERON_ALPHA_RESPONSE↔INTERFERON_GAMMA_RESPONSEr = +0.95
  • IL6_JAK_STAT3_SIGNALING↔INFLAMMATORY_RESPONSEr = +0.94
  • COMPLEMENT↔INFLAMMATORY_RESPONSEr = +0.93
  • IL2_STAT5_SIGNALING↔INFLAMMATORY_RESPONSEr = +0.92
  • COMPLEMENT↔IL6_JAK_STAT3_SIGNALINGr = +0.91
  • COMPLEMENT↔IL2_STAT5_SIGNALINGr = +0.91
  • IL2_STAT5_SIGNALING↔IL6_JAK_STAT3_SIGNALINGr = +0.91
  • ALLOGRAFT_REJECTION↔IL6_JAK_STAT3_SIGNALINGr = +0.91
  • ALLOGRAFT_REJECTION↔INFLAMMATORY_RESPONSEr = +0.90

Strongest mutual exclusions

Derived

Pathways that don't co-occur.

  • KRAS_SIGNALING_DN⊥UNFOLDED_PROTEIN_RESPONSEr = -0.71
  • KRAS_SIGNALING_DN⊥PROTEIN_SECRETIONr = -0.70
  • DNA_REPAIR⊥KRAS_SIGNALING_DNr = -0.68
  • KRAS_SIGNALING_DN⊥MYC_TARGETS_V1r = -0.63
  • KRAS_SIGNALING_DN⊥MITOTIC_SPINDLEr = -0.61
  • KRAS_SIGNALING_DN⊥PI3K_AKT_MTOR_SIGNALINGr = -0.59
  • MYC_TARGETS_V1⊥MYOGENESISr = -0.58
  • E2F_TARGETS⊥MYOGENESISr = -0.57
  • G2M_CHECKPOINT⊥MYOGENESISr = -0.56
  • KRAS_SIGNALING_DN⊥MTORC1_SIGNALINGr = -0.54