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Variant atlas

200 annotated variants across the profiled kinome. Each entry links to drug activity on-variant vs. wild-type.

P
116
Point
C
40
Compound
I
20
Indel
F
20
Fusion
U
4
Unknown
200 of 200 shown
ABL1 (E255K)
pointp.E255K
ABL1 (E255V)
pointp.E255V
ABL1 (F317I)
pointp.F317I
ABL1 (F317L)
pointp.F317L
ABL1 (G250E)
pointp.G250E
ABL1 (H396P)
pointp.H396P
ABL1 (M351T)
pointp.M351T
ABL1 (Q252H)
pointp.Q252H
ABL1 (T315I)
pointp.T315I
ABL1 (V299L)
pointp.V299L
ABL1 (Y245F)
pointp.Y245F
ABL1 (Y245F/Y412F)
compoundp.Y245F;p.Y412F
ABL1 (Y253F)
pointp.Y253F
ABL1 (Y253H)
pointp.Y253H
ALK2 (Q207D)
pointp.Q207D
ALK2 (R206H)
pointp.R206H
AKT1 (E17K)
pointp.E17K
AKT2 (E17K)
pointp.E17K
AKT3 (E17K)
pointp.E17K
AKT3 (G171R)
pointp.G171R
ALK
fusionALK · partner NPM1
ALK (C1156Y)
pointp.C1156Y
ALK (F1174L)
pointp.F1174L
ALK (F1174L)-NPM1
fusionp.F1174L · partner NPM1 (F1174L)
ALK (F1174S)
pointp.F1174S
ALK (G1202R)
pointp.G1202R
ALK (G1269A)
pointp.G1269A
ALK (G1269S)
pointp.G1269S
ALK (I1171N/D1203N)
compoundp.I1171N;p.D1203N
ALK (L1152R)
pointp.L1152R
ALK (L1196M)
pointp.L1196M
ALK (L1196M/G1202R)
compoundp.L1196M;p.G1202R
ALK (R1275Q)
pointp.R1275Q
ALK (S1206R)
pointp.S1206R
ALK (T1151-L1152insT)
indelp.T1151-L1152insT
ALK (T1151M)
pointp.T1151M
PKN1-ANXA4 (Aex2Pex13)
fusionANXA4-PKN1 · partner ANXA4 (Aex2Pex13)
Aurora B (G160L)
pointp.G160L
AXL (R499C)
pointp.R499C
RET-BCR
fusionBCR-RET · partner BCR
BRAF (G464V)
pointp.G464V
BRAF (G469A)
pointp.G469A
BRAF (K601E)
pointp.K601E
BRAF (L597V)
pointp.L597V
BRAF (R506_K507insVLR)
indelp.R506_K507insVLR
BRAF (T599_V600insT)
indelp.T599_V600insT
BRAF (V599E)
pointp.V599E
BRAF (V600A)
pointp.V600A
BRAF (V600D)
pointp.V600D
BRAF (V600K)
pointp.V600K
BRAF (d485-489/P490Y)
compoundp.485_489del;p.P490Y
BTK (C481S)
pointp.C481S
BTK (E41K)
pointp.E41K
BTK (P190K)
pointp.P190K
BTK (T474I)
pointp.T474I
BTK (Y485F)
pointp.Y485F
RET-CCDC6 (PTC1)
fusionCCDC6-RET · partner CCDC6 (PTC1)
CHK2 (I157T)
pointp.I157T
CK1a1 (E42C)
pointp.E42C
CK1a1 (I35C)
pointp.I35C
CK1epsilon (R178C)
pointp.R178C
DDR2 (N456S)
pointp.N456S
DDR2 (T654M)
pointp.T654M
PKA-DNAJB1
fusionp.DNAJB1-PKA fusion · partner DNAJB1
EGFR (A763_Y764insFHEA)
indelp.A763_Y764insFHEA
EGFR (A763_Y764insFQEA)
indelp.A763_Y764insFQEA
EGFR (A767_S768insTLA)
indelp.A767_S768insTLA
EGFR (C775S/T790M/L858R)
compoundp.C775S;p.T790M;p.L858R
EGFR (C797A)
pointp.C797A
EGFR (C797G/L858R)
compoundp.C797G;p.L858R
EGFR (C797S)
pointp.C797S
EGFR (C797S/L858R)
compoundp.C797S;p.L858R
EGFR (D761Y)
pointp.D761Y
EGFR (D770GY)
pointp.D770GY
EGFR (D770_N771insG)
indelp.D770_N771insG
EGFR (D770_N771insNPG)
indelp.D770_N771insNPG
EGFR (D770_N771insNPG/T790M)
compoundp.D770_N771insNPG;p.T790M
EGFR (G719C)
pointp.G719C
EGFR (G719D)
pointp.G719D
EGFR (G719S)
pointp.G719S
EGFR (K716A)
pointp.K716A
EGFR (K716A/C797S/L858R)
compoundp.K716A;p.C797S;p.L858R
EGFR (K716A/T790M/C797S/L858R)
compoundp.K716A;p.T790M;p.C797S;p.L858R
EGFR (K716Q/L718Q)
compoundp.K716Q;p.L718Q
EGFR (K728A)
pointp.K728A
EGFR (K728A/T790M/C797S/L858R)
pointp.R999A
EGFR (L718Q)
pointp.L718Q
EGFR (L747S)
pointp.L747S
EGFR (L792F)
pointp.L792F
EGFR (L792F/L858R)
compoundp.L792F;p.L858R
EGFR (L792H)
pointp.L792H
EGFR (L792H/C797S/L858R)
compoundp.L792H;p.C797S;p.L858R
EGFR (L792H/L858R)
compoundp.L792H;p.L858R
EGFR (L858R)
pointp.L858R
EGFR (L861Q)
pointp.L861Q
EGFR (N771_P772insH)
indelp.N771_P772insH
EGFR (N771_P772insN)
indelp.N771_P772insN
EGFR (R999A)
pointp.R999A
EGFR (S768I)
pointp.S768I
EGFR (T790M)
pointp.T790M
EGFR (T790M/C797G/L858R)
compoundp.746_750del;p.T790M;p.L858R
EGFR (T790M/C797S)
compoundp.T790M;p.C797S
EGFR (T790M/C797S/L858R)
compoundp.T790M;p.C797S;p.L858R
EGFR (T790M/L792F/C797S/L858R)
compoundp.T790M;p.L792F;p.C797S;p.L858R
EGFR (T790M/L792F/L858R)
compoundp.T790M;p.L792F;p.L858R
EGFR (T790M/L792H/C797S/L858R)
compoundp.T790M;p.L792H;p.C797S;p.L858R
EGFR (T790M/L792H/L858R)
compoundp.T790M;p.L792H;p.L858R
EGFR (T790M/L858R)
compoundp.T790M;p.L858R
EGFR (V769_D770insGE)
indelp.V769_D770insGE
EGFR (V948R)
pointp.V948R
EGFR (d746)
pointp.d746
EGFR (d746-750)
unknownEGFR
EGFR (d746-750/C775S/T790M/L858R)
compoundp.746_750del;p.C775S;p.T790M;p.L858R
EGFR (d746-750/C797A)
compoundp.746_750del;p.C797A
EGFR (d746-750/C797S)
compoundp.746_750del;p.C797S
EGFR (d746-750/G724S)
compoundp.746_750del;p.G724S
EGFR (d746-750/S768I)
compoundp.746_750del;p.S768I
EGFR (d746-750/T790M)
pointp.T790M
EGFR (d746-750/T790M/C797S)
compoundp.746_750del;p.T790M;p.C797S
EGFR (d746-750/T790M/C797S/L858R)
compoundp.746_750del;p.T790M;p.C797S;p.L858R
EGFR (d746-750/T790M/L792F)
compoundp.746_750del;p.T790M;p.L792F
EGFR (d746-750/T790M/L792H)
compoundp.746_750del;p.T790M;p.L792H
EGFR (d746-750/T790M/L798I)
compoundp.746_750del;p.T790M;p.L798I
EGFR (d746-750/T790M/L858R)
compoundp.746_750del;p.T790M;p.L858R
EGFR (d747-749)
indelp.747_749del
EGFR (d747-749/A750P)
pointp.A750P
EGFR (d747-752/P753S)
pointp.P753S
EGFR (d752-759)
unknownEGFR
ALK (F1174L)-EML4
fusionp.F1174L · partner EML4 (F1174L)
ALK-EML4 (Eex13Aex20)
fusionEML4-ALK · partner EML4 (Eex13Aex20)
EML4-ALK
fusionEML4-ALK · partner EML4 (Eex14Aex20)
ERBB2 (A775_G776insYVMA)
indelp.A775_G776insYVMA
ERBB2 (D769H)
pointp.D769H
ERBB2 (D769Y)
pointp.D769Y
ERBB2 (P1170A)
pointp.P1170A
ERBB2 (P780_Y781insGSP)
indelp.P780_Y781insGSP
ERBB2 (R896C)
pointp.R896C
ERBB2 (V777L)
pointp.V777L
ERBB2 (V777_G778insCG)
indelp.V777_G778insCG
ERBB2 (V956R)
pointp.V956R
ERN1/IRE1 (R727A)
pointp.R727A
ERN1/IRE1 (R727A/R728A)
compoundp.R727A;p.R728A
ERN1/IRE1 (R728A)
pointp.R728A
BRAF-FAM131B (Fex2Bex9)
fusionFAM131B-BRAF · partner FAM131B (Fex2Bex9)
FGFR1 (V561M)
pointp.V561M
FGFR1 (W666R)
pointp.W666R
FGFR1OP-FGFR1
fusionFGFR1OP-FGFR1 · partner FGFR1
FGFR2 (C491A)
pointp.C491A
FGFR2 (C491A/V564I)
compoundp.C491A;p.V564I
FGFR2 (C491A/V564L)
compoundp.C491A;p.V564L
FGFR2 (C491F)
pointp.C491F
FGFR2 (C491S)
pointp.C491S
FGFR2 (C491S/V564L)
compoundp.C491S;p.V564L
FGFR2 (E565A)
pointp.E565A
FGFR2 (E565G)
pointp.E565G
FGFR2 (K526E)
pointp.K526E
FGFR2 (K641R)
pointp.K641R
FGFR2 (K659N)
pointp.K659N
FGFR2 (M420I)
pointp.M420I
FGFR2 (N549H)
pointp.N549H
FGFR2 (N549K)
pointp.N549K
FGFR2 (R612T)
pointp.R612T
FGFR2 (V564F)
pointp.V564F
FGFR2 (V564I)
pointp.V564I
FGFR2 (V564L)
pointp.V564L
FGFR3 (G697C)
pointp.G697C
FGFR3 (K650E)
pointp.K650E
FGFR3 (K650M)
pointp.K650M
FGFR3 (K650Q)
pointp.K650Q
FGFR3 (V555M)
pointp.V555M
FGFR4 (N535K)
pointp.N535K
FGFR4 (V550E)
pointp.V550E
FGFR4 (V550L)
pointp.V550L
FGFR4 (V550M)
pointp.V550M
PDGFRa-FIP1L1
unknownFIP1L1-PDGFRA
FLT3 (D835Y)
pointp.D835Y
FLT3 (F594_R595insR)
indelp.F594_R595insR
FLT3 (F594_R595insREY)
indelp.F594_R595insREY
FLT3 (F691L/D835Y)
compoundp.F691L;p.D835Y
FLT3 (ITD)
indelp.internal tandem duplication aa591-601
FLT3 (ITD)-NPOS
fusionp.L610_E611insCSSDNEYFYVDFREYEYDLKWEF-PRENL · partner NPOS (ITD)
FLT3 (ITD)-W51
fusionp.L601_K602insREYEYDL · partner W51 (ITD)
FLT3 (R595_E596insEY)
indelp.R595_E596insEY
FLT3 (Y591-V592insVDFREYEYD/D835Y)
compoundp.Y591-V592insVDFREYEYD;p.D835Y
FLT3 (Y591-V592insVDFREYEYD/F691L)
compoundp.Y591-V592insVDFREYEYD;p.F691L
FLT3 (Y591_V592insVDFREYEYD)
indelp.Y591_V592insVDFREYEYD
FYN (Y531F)
pointp.Y531F
ROS1-GOPC
fusionGOPC-ROS1 · partner GOPC
GSK3b (C199A)
pointp.C199A
JAK2 (V617F)
pointp.V617F
BRAF-KIAA1549 (Kex15Bex9)
fusionKIAA1549-BRAF · partner KIAA1549 (Kex15Bex9)
BRAF-KIAA1549 (Kex16Bex9)
fusionKIAA1549-BRAF · partner KIAA1549 (Kex16Bex9)
KIF5B-ALK
fusionKIF5B-ALK · partner KIF5B (Kex24Aex20)
c-MET-KIF5B (Kex24Mex14)
unknownKIF5B-MET
RET (V804L)-KIF5B
fusionp.Fusion;p.V804L · partner KIF5B (V804L)
RET (V804M)-KIF5B
fusionp.Fusion;p.V804M · partner KIF5B (V804M)
RET-KIF5B (Kex15Rex14)
fusionKIF5B-RET · partner KIF5B (Kex15Rex14)
c-Kit (A829P)
pointp.A829P
c-Kit (D816E)
pointp.D816E
c-Kit (D816F)
pointp.D816F