Research Use Only. KIRhub outputs are computational research artifacts. They are not validated for clinical decision-making, diagnosis, or treatment.
KIRhub 2.0
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EMT differential expression — volcano

MeasuredDerived

Each point is one of 514 profiled kinases. Points to the right are higher in mesenchymal samples; points to the left in epithelial. Blue markers fall in the “biologically interesting” quadrants (|log2 FC| ≥ 1 and |Δlog2 expression| ≥ 1).

514 kinases plotted. Vertical dotted lines mark log2 FC = ±1.

EMT / mesenchymal druggability — which inhibitors hit this program (Table S9) →

Mesenchymal Reversal Workbench — combination designer, resistance-aware targeting, and per-sample reversal across the tumor atlas →