UniProt P31751 · PDB · AlphaFold · Substrate: Crosstide · Clone: full-length
Top inhibitors
| # | Drug | Inhibition | Residual | KISS | Gini |
|---|---|---|---|---|---|
| 1 | Capivasertib | 95.3% | 4.7% | 96.48 | 0.644 |
| 2 | Netarsudil | 25.2% | 74.8% | 93.22 | 0.676 |
| 3 | Midostaurin | 21.1% | 78.9% | 78.64 | 0.500 |
| 4 | Sunitinib | 20.4% | 79.6% | 91.73 | 0.524 |
| 5 | Ponatinib | 19.5% | 80.5% | 78.23 | 0.534 |
| 6 | Acalabrutinib | 13.2% | 86.8% | 99.50 | 0.670 |
| 7 | Quizartinib | 12.8% | 87.2% | 99.50 | 0.737 |
| 8 | Crizotinib | 12.5% | 87.5% | 91.39 | 0.581 |
| 9 | Tepotinib | 11.5% | 88.5% | 99.75 | 0.727 |
| 10 | Abemaciclib | 11.4% | 88.6% | 91.48 | 0.563 |
| 11 | Vandetanib | 9.7% | 90.3% | 95.74 | 0.723 |
| 12 | Pirtobrutinib | 9.1% | 90.9% | 99.49 | 0.656 |
| 13 | Neratinib | 9.0% | 91.0% | 93.18 | 0.597 |
| 14 | Ibrutinib | 7.5% | 92.5% | 94.74 | 0.723 |
| 15 | Vemurafenib | 7.2% | 92.8% | 96.49 | 0.598 |
| 16 | Erlotinib | 7.2% | 92.8% | 99.75 | 0.695 |
| 17 | Brigatinib | 7.1% | 92.9% | 82.96 | 0.513 |
| 18 | Larotrectinib | 6.0% | 94.0% | 99.25 | 0.710 |
| 19 | Deucravacitinib | 5.6% | 94.4% | 98.99 | 0.718 |
| 20 | Lazertinib | 5.4% | 94.6% | 97.47 | 0.674 |
Paralog block
No paralog group registered for this kinase.
EMT expression
- Mesenchymal log2(TPM+1): 5.81
- Epithelial log2(TPM+1): 5.68
- Fold change: 0.12
- Status: No significant change
Selectivity landscape vs inhibition on AKT2
Each point is one of the 92 approved drugs; color = inhibition % on AKT2.
Mutation lollipop
Cancer-associated mutations plotted by residue position. Marker size + color scale with the number of distinct cancer reports.
Variants (1)
Mutation × cancer associations
| Mutation | Cancer | Organ | Source |
|---|---|---|---|
| E17K | carcinoma_lung | Lung | ref |
| E17K | carcinoma_urinary_tract | Bladder | ref |
| E17K | carcinoma_breast | Breast | ref |
| E17K | carcinoma_thyroid | Thyroid | ref |
| E17K | carcinoma_upper_aerodigestive_tract | Brain/CNS | ref |
| E17K | BRCA-EU | Breast | ref |
| E17K | BRCA-UK | Breast | ref |
| E17K | LUSC-US | Lung | ref |
| E17K | SKCA-BR | Skin | ref |
| E17K | THCA-US | Thyroid | ref |
| E17K | LUSC | Lung | ref |
| E17K | THCA | Thyroid | ref |
3D structure
Embedded NGL viewer pulls a representative PDB entry (or AlphaFold model if no experimental structure is registered). Heavy bundle — loaded only on demand.
Annotations
Sign in to read and post annotations.
Loading…