Research Use Only. KIRhub outputs are computational research artifacts. They are not validated for clinical decision-making, diagnosis, or treatment.
KIRhub 2.0
Sign in

UniProt O14965 · PDB · AlphaFold · Substrate: Kemptide · Clone: full length

Top inhibitors

MeasuredDerived
#DrugInhibitionResidualKISSGini

Paralog block

No paralog group registered for this kinase.

EMT expression

MeasuredDerived
  • Mesenchymal log2(TPM+1): 6.16
  • Epithelial log2(TPM+1): 5.98
  • Fold change: 0.18
  • Status: No significant change

Selectivity landscape vs inhibition on AURKA

MeasuredDerived

Each point is one of the 92 approved drugs; color = inhibition % on AURKA.

3D structure

Embedded NGL viewer pulls a representative PDB entry (or AlphaFold model if no experimental structure is registered). Heavy bundle — loaded only on demand.

Annotations

Sign in to read and post annotations.

Loading…