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CDK12/CCNK(CDK12/cyclin K)

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UniProt CDK12: Q9NYV4; cyclin K: O75909 · PDB · AlphaFold (Q9NYV4), AlphaFold (O75909) · Substrate: Pol2-CTD · Clone: aa 715-1052/ aa 11-267

Top inhibitors

MeasuredDerived
#DrugInhibitionResidualKISSGini

Paralog block

No paralog group registered for this kinase.

EMT expression

MeasuredDerived

Not in the EMT expression panel.

Selectivity landscape vs inhibition on CDK12/CCNK

MeasuredDerived

Each point is one of the 92 approved drugs; color = inhibition % on CDK12/CCNK.

3D structure

Embedded NGL viewer pulls a representative PDB entry (or AlphaFold model if no experimental structure is registered). Heavy bundle — loaded only on demand.

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