UniProt Q09013 · PDB · AlphaFold · Substrate: SGKtide · Clone: full-length
Top inhibitors
| # | Drug | Inhibition | Residual | KISS | Gini |
|---|---|---|---|---|---|
| 1 | Darovasertib | 27.3% | 72.7% | 96.99 | 0.719 |
| 2 | Bosutinib | 24.0% | 76.0% | 87.22 | 0.555 |
| 3 | Fostamatinib | 10.3% | 89.8% | 96.74 | 0.613 |
| 4 | Trametinib | 10.2% | 89.8% | 99.50 | 0.718 |
| 5 | Imatinib | 10.0% | 90.0% | 99.00 | 0.718 |
| 6 | Ribociclib | 8.7% | 91.3% | 99.25 | 0.729 |
| 7 | Nintedanib | 8.1% | 91.9% | 90.23 | 0.608 |
| 8 | Baricitinib | 8.1% | 91.9% | 97.99 | 0.616 |
| 9 | Ponatinib | 8.0% | 92.0% | 78.23 | 0.534 |
| 10 | Everolimus | 7.5% | 92.5% | 100.00 | 0.706 |
| 11 | Ruxolitinib | 7.2% | 92.8% | 98.25 | 0.592 |
| 12 | Crizotinib | 7.1% | 92.9% | 91.39 | 0.581 |
| 13 | Vemurafenib | 6.6% | 93.4% | 96.49 | 0.598 |
| 14 | Entrectinib | 6.5% | 93.5% | 93.69 | 0.671 |
| 15 | Dacomitinib | 6.4% | 93.6% | 97.99 | 0.664 |
| 16 | Ceritinib | 6.2% | 93.8% | 95.44 | 0.618 |
| 17 | Midostaurin | 6.0% | 94.0% | 78.64 | 0.500 |
| 18 | Lorlatinib | 5.3% | 94.7% | 97.24 | 0.694 |
| 19 | Abemaciclib | 5.0% | 95.0% | 91.48 | 0.563 |
| 20 | Dasatinib | 4.8% | 95.2% | 87.97 | 0.699 |
Paralog block
No paralog group registered for this kinase.
EMT expression
- Mesenchymal log2(TPM+1): 4.67
- Epithelial log2(TPM+1): 4.17
- Fold change: 0.50
- Status: No significant change
Selectivity landscape vs inhibition on DMPK
Each point is one of the 92 approved drugs; color = inhibition % on DMPK.
3D structure
Embedded NGL viewer pulls a representative PDB entry (or AlphaFold model if no experimental structure is registered). Heavy bundle — loaded only on demand.
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