UniProt P32298 · PDB · AlphaFold · Substrate: Casein · Clone: full-length
Top inhibitors
| # | Drug | Inhibition | Residual | KISS | Gini |
|---|---|---|---|---|---|
| 1 | Alectinib | 71.1% | 28.9% | 95.49 | 0.651 |
| 2 | Ceritinib | 42.7% | 57.3% | 95.44 | 0.618 |
| 3 | Midostaurin | 19.5% | 80.5% | 78.64 | 0.500 |
| 4 | Brigatinib | 18.1% | 81.9% | 82.96 | 0.513 |
| 5 | Lorlatinib | 18.0% | 82.0% | 97.24 | 0.694 |
| 6 | Darovasertib | 17.8% | 82.2% | 96.99 | 0.719 |
| 7 | Entrectinib | 14.4% | 85.6% | 93.69 | 0.671 |
| 8 | Capivasertib | 14.4% | 85.6% | 96.48 | 0.644 |
| 9 | Quizartinib | 13.9% | 86.1% | 99.50 | 0.737 |
| 10 | Canertinib | 13.0% | 87.0% | 96.49 | 0.671 |
| 11 | Sunitinib | 11.6% | 88.4% | 91.73 | 0.524 |
| 12 | Repotrectinib | 11.0% | 89.0% | 84.21 | 0.608 |
| 13 | Nintedanib | 10.6% | 89.4% | 90.23 | 0.608 |
| 14 | Alpelisib | 10.0% | 90.0% | 97.22 | 0.720 |
| 15 | Crizotinib | 9.8% | 90.2% | 91.39 | 0.581 |
| 16 | Bosutinib | 9.4% | 90.6% | 87.22 | 0.555 |
| 17 | Ponatinib | 8.7% | 91.3% | 78.23 | 0.534 |
| 18 | Defactinib | 7.8% | 92.2% | 92.68 | 0.450 |
| 19 | Vemurafenib | 7.6% | 92.4% | 96.49 | 0.598 |
| 20 | Cobimetinib | 7.3% | 92.7% | 100.00 | 0.644 |
Paralog block
No paralog group registered for this kinase.
EMT expression
- Mesenchymal log2(TPM+1): 1.85
- Epithelial log2(TPM+1): 1.69
- Fold change: 0.16
- Status: No significant change
Selectivity landscape vs inhibition on GRK4
Each point is one of the 92 approved drugs; color = inhibition % on GRK4.
3D structure
Embedded NGL viewer pulls a representative PDB entry (or AlphaFold model if no experimental structure is registered). Heavy bundle — loaded only on demand.
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