UniProt P34947 · PDB · AlphaFold · Substrate: Casein · Clone: full-length
Top inhibitors
| # | Drug | Inhibition | Residual | KISS | Gini |
|---|---|---|---|---|---|
| 1 | Lorlatinib | 20.1% | 79.9% | 97.24 | 0.694 |
| 2 | Repotrectinib | 17.0% | 83.0% | 84.21 | 0.608 |
| 3 | Midostaurin | 16.2% | 83.8% | 78.64 | 0.500 |
| 4 | Nintedanib | 15.1% | 84.9% | 90.23 | 0.608 |
| 5 | Darovasertib | 13.3% | 86.7% | 96.99 | 0.719 |
| 6 | Pemigatinib | 10.6% | 89.4% | 98.23 | 0.718 |
| 7 | Ceritinib | 8.2% | 91.8% | 95.44 | 0.618 |
| 8 | Crizotinib | 8.2% | 91.8% | 91.39 | 0.581 |
| 9 | Capivasertib | 7.4% | 92.6% | 96.48 | 0.644 |
| 10 | Tofacitinib | 7.1% | 92.9% | 99.25 | 0.684 |
| 11 | Defactinib | 6.8% | 93.2% | 92.68 | 0.450 |
| 12 | Alectinib | 6.5% | 93.5% | 95.49 | 0.651 |
| 13 | Bosutinib | 6.4% | 93.6% | 87.22 | 0.555 |
| 14 | Asciminib | 6.3% | 93.7% | 100.00 | 0.602 |
| 15 | Abrocitinib | 5.8% | 94.2% | 99.50 | 0.581 |
| 16 | Pexidartinib | 5.6% | 94.4% | 99.49 | 0.631 |
| 17 | Baricitinib | 5.4% | 94.6% | 97.99 | 0.616 |
| 18 | Zanubrutinib | 5.1% | 94.9% | 98.24 | 0.788 |
| 19 | Ruxolitinib | 5.0% | 95.0% | 98.25 | 0.592 |
| 20 | Entrectinib | 5.0% | 95.0% | 93.69 | 0.671 |
Paralog block
No paralog group registered for this kinase.
EMT expression
- Mesenchymal log2(TPM+1): 2.08
- Epithelial log2(TPM+1): 1.18
- Fold change: 0.90
- Status: No significant change
Selectivity landscape vs inhibition on GRK5
Each point is one of the 92 approved drugs; color = inhibition % on GRK5.
3D structure
Embedded NGL viewer pulls a representative PDB entry (or AlphaFold model if no experimental structure is registered). Heavy bundle — loaded only on demand.
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