UniProt P43250 · PDB · AlphaFold · Substrate: Casein · Clone: full-length
Top inhibitors
| # | Drug | Inhibition | Residual | KISS | Gini |
|---|---|---|---|---|---|
| 1 | Repotrectinib | 44.1% | 55.9% | 84.21 | 0.608 |
| 2 | Lorlatinib | 42.0% | 58.0% | 97.24 | 0.694 |
| 3 | Midostaurin | 38.0% | 62.0% | 78.64 | 0.500 |
| 4 | Sunitinib | 26.1% | 73.9% | 91.73 | 0.524 |
| 5 | Capivasertib | 22.4% | 77.6% | 96.48 | 0.644 |
| 6 | Nintedanib | 21.6% | 78.4% | 90.23 | 0.608 |
| 7 | Ceritinib | 19.6% | 80.4% | 95.44 | 0.618 |
| 8 | Larotrectinib | 19.2% | 80.8% | 99.25 | 0.710 |
| 9 | Defactinib | 18.7% | 81.3% | 92.68 | 0.450 |
| 10 | Cobimetinib | 18.1% | 81.9% | 100.00 | 0.644 |
| 11 | Abrocitinib | 15.8% | 84.2% | 99.50 | 0.581 |
| 12 | Tivozanib | 15.8% | 84.2% | 92.42 | 0.673 |
| 13 | Pirtobrutinib | 14.9% | 85.1% | 99.49 | 0.656 |
| 14 | Gedatolisib | 14.2% | 85.8% | 99.75 | 0.611 |
| 15 | Mitapivat | 13.8% | 86.2% | 100.00 | 0.625 |
| 16 | Erlotinib | 12.8% | 87.2% | 99.75 | 0.695 |
| 17 | Zanubrutinib | 12.2% | 87.8% | 98.24 | 0.788 |
| 18 | Brigatinib | 12.1% | 87.9% | 82.96 | 0.513 |
| 19 | Darovasertib | 11.9% | 88.1% | 96.99 | 0.719 |
| 20 | Alectinib | 11.8% | 88.2% | 95.49 | 0.651 |
Paralog block
No paralog group registered for this kinase.
EMT expression
- Mesenchymal log2(TPM+1): 4.59
- Epithelial log2(TPM+1): 4.80
- Fold change: -0.21
- Status: No significant change
Selectivity landscape vs inhibition on GRK6
Each point is one of the 92 approved drugs; color = inhibition % on GRK6.
3D structure
Embedded NGL viewer pulls a representative PDB entry (or AlphaFold model if no experimental structure is registered). Heavy bundle — loaded only on demand.
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