KIT(c-Kit)
Sign in to save this workspaceUniProt P10721 · PDB · AlphaFold · Substrate: pEY · Clone: aa 544-976
Top inhibitors
| # | Drug | Inhibition | Residual | KISS | Gini |
|---|
Paralog block
No paralog group registered for this kinase.
EMT expression
- Mesenchymal log2(TPM+1): 1.37
- Epithelial log2(TPM+1): 0.96
- Fold change: 0.40
- Status: No significant change
Selectivity landscape vs inhibition on KIT
Each point is one of the 92 approved drugs; color = inhibition % on KIT.
Variants (22)
c-Kit (A829P)
point
c-Kit (D816E)
point
c-Kit (D816F)
point
c-Kit (D816H)
point
c-Kit (D816I)
point
c-Kit (D816V)
point
c-Kit (D816Y)
point
c-Kit (D820E)
point
c-Kit (D820Y)
point
c-Kit (N822K)
point
c-Kit (T670I)
point
c-Kit (V559A)
point
c-Kit (V559D)
point
c-Kit (V559D/T670I)
compound
c-Kit (V559D/V654A)
compound
c-Kit (V560G)
point
c-Kit (V560G/D816V)
compound
c-Kit (V560G/N822K)
compound
c-Kit (V654A)
point
c-Kit (Y823D)
point
c-Kit (d557-558)
indel
c-Kit (d557-558/Y823D)
compound
3D structure
Embedded NGL viewer pulls a representative PDB entry (or AlphaFold model if no experimental structure is registered). Heavy bundle — loaded only on demand.
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