UniProt Q9P1W9 · PDB · AlphaFold · Substrate: Pim2tide · Clone: full-length
Top inhibitors
| # | Drug | Inhibition | Residual | KISS | Gini |
|---|---|---|---|---|---|
| 1 | Abemaciclib | 48.4% | 51.6% | 91.48 | 0.563 |
| 2 | Alectinib | 20.6% | 79.4% | 95.49 | 0.651 |
| 3 | Alpelisib | 16.5% | 83.5% | 97.22 | 0.720 |
| 4 | Lapatinib | 15.9% | 84.1% | 99.25 | 0.616 |
| 5 | Fedratinib | 15.0% | 85.0% | 96.21 | 0.576 |
| 6 | Vemurafenib | 14.7% | 85.3% | 96.49 | 0.598 |
| 7 | Lenvatinib | 13.8% | 86.2% | 97.74 | 0.726 |
| 8 | Regorafenib | 13.6% | 86.4% | 95.99 | 0.719 |
| 9 | Asciminib | 12.8% | 87.2% | 100.00 | 0.602 |
| 10 | Capivasertib | 12.6% | 87.4% | 96.48 | 0.644 |
| 11 | Ruxolitinib | 12.5% | 87.5% | 98.25 | 0.592 |
| 12 | Entrectinib | 11.8% | 88.2% | 93.69 | 0.671 |
| 13 | Crizotinib | 11.4% | 88.6% | 91.39 | 0.581 |
| 14 | Everolimus | 10.6% | 89.4% | 100.00 | 0.706 |
| 15 | Binimetinib | 9.6% | 90.4% | 100.00 | 0.689 |
| 16 | Ponatinib | 8.9% | 91.1% | 78.23 | 0.534 |
| 17 | Paxalisib | 6.4% | 93.6% | 99.75 | 0.609 |
| 18 | Pexidartinib | 5.9% | 94.1% | 99.49 | 0.631 |
| 19 | Remibrutinib | 5.6% | 94.4% | 99.50 | 0.721 |
| 20 | Ceritinib | 5.4% | 94.6% | 95.44 | 0.618 |
Paralog block
No paralog group registered for this kinase.
EMT expression
- Mesenchymal log2(TPM+1): 2.76
- Epithelial log2(TPM+1): 3.00
- Fold change: -0.24
- Status: No significant change
Selectivity landscape vs inhibition on PIM2
Each point is one of the 92 approved drugs; color = inhibition % on PIM2.
3D structure
Embedded NGL viewer pulls a representative PDB entry (or AlphaFold model if no experimental structure is registered). Heavy bundle — loaded only on demand.
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