ROS1(ROS/ROS1)
Sign in to save this workspaceUniProt P08922 · PDB · AlphaFold · Substrate: IGF-1Rtide · Clone: cytoplasmic
Top inhibitors
| # | Drug | Inhibition | Residual | KISS | Gini |
|---|
Paralog block
No paralog group registered for this kinase.
EMT expression
- Mesenchymal log2(TPM+1): 0.71
- Epithelial log2(TPM+1): 0.07
- Fold change: 0.63
- Status: No significant change
Selectivity landscape vs inhibition on ROS1
Each point is one of the 92 approved drugs; color = inhibition % on ROS1.
Mutation lollipop
Cancer-associated mutations plotted by residue position. Marker size + color scale with the number of distinct cancer reports.
Variants (4)
Mutation × cancer associations
| Mutation | Cancer | Organ | Source |
|---|---|---|---|
| G2032R | carcinoma_lung | Lung | ref |
| G2101A | carcinoma_lung | Lung | ref |
| G2101C | carcinoma_lung | Lung | ref |
| L2086F | carcinoma_lung | Lung | ref |
3D structure
Embedded NGL viewer pulls a representative PDB entry (or AlphaFold model if no experimental structure is registered). Heavy bundle — loaded only on demand.
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