UniProt Q6SA08 · PDB · AlphaFold · Substrate: RS Peptide Long + Mn · Clone: full length
Top inhibitors
| # | Drug | Inhibition | Residual | KISS | Gini |
|---|---|---|---|---|---|
| 1 | Capivasertib | 9.3% | 90.7% | 96.48 | 0.644 |
| 2 | Remibrutinib | 4.5% | 95.5% | 99.50 | 0.721 |
| 3 | Canertinib | 1.5% | 98.5% | 96.49 | 0.671 |
| 4 | Darovasertib | 0.0% | 100.0% | 96.99 | 0.719 |
| 5 | Inavolisib | 0.0% | 100.0% | 100.00 | 0.679 |
| 6 | Quizartinib | 0.0% | 100.0% | 99.50 | 0.737 |
| 7 | Repotrectinib | 0.0% | 100.0% | 84.21 | 0.608 |
Paralog block
No paralog group registered for this kinase.
EMT expression
- Mesenchymal log2(TPM+1): 1.17
- Epithelial log2(TPM+1): 1.51
- Fold change: -0.34
- Status: No significant change
Selectivity landscape vs inhibition on TSSK4
Each point is one of the 92 approved drugs; color = inhibition % on TSSK4.
3D structure
Embedded NGL viewer pulls a representative PDB entry (or AlphaFold model if no experimental structure is registered). Heavy bundle — loaded only on demand.
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