Research Use Only. KIRhub outputs are computational research artifacts. They are not validated for clinical decision-making, diagnosis, or treatment.
KIRhub 2.0· v2
Ependymoma Hub
V1V2
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ABL1

RBC: ABL1 · Substrate: Abltide ·

Top inhibitors

MeasuredDerived
DrugInhibition %Gini
Ponatinib100.00.53
Nintedanib99.90.61
Bosutinib99.70.55
Axitinib99.40.69
Dasatinib98.60.70
Nilotinib98.00.77
Crizotinib97.00.58
Tivozanib95.80.67
Vandetanib95.70.72
Repotrectinib93.60.61
Pacritinib92.00.45
Canertinib91.60.67
Erdafitinib90.90.74
Imatinib86.20.72
Ripretinib82.90.67

Known variants

Cancer associations

MutationCancer typeOrganSource
E255Khaematopoietic_neoplasm_haematopoietic_and_lymphoid_tissueBlood/Lymphatic Systemhttps://doi.org/10.1093/nar/gkaa945
E255Klymphoid_neoplasm_haematopoietic_and_lymphoid_tissueBlood/Lymphatic Systemhttps://doi.org/10.1093/nar/gkaa945
E255Kcarcinoma_upper_aerodigestive_tractStomach/Digestive Tracthttps://doi.org/10.1093/nar/gkaa945
E255Kcarcinoma_penisGenitourinary systemhttps://doi.org/10.1093/nar/gkaa945
E255Vhaematopoietic_neoplasm_haematopoietic_and_lymphoid_tissueBlood/Lymphatic Systemhttps://doi.org/10.1093/nar/gkaa945
E255Vlymphoid_neoplasm_haematopoietic_and_lymphoid_tissueBlood/Lymphatic Systemhttps://doi.org/10.1093/nar/gkaa945
F317Ihaematopoietic_neoplasm_haematopoietic_and_lymphoid_tissueBlood/Lymphatic Systemhttps://doi.org/10.1093/nar/gkaa945
F317Lhaematopoietic_neoplasm_haematopoietic_and_lymphoid_tissueBlood/Lymphatic Systemhttps://doi.org/10.1093/nar/gkaa945
F317Llymphoid_neoplasm_haematopoietic_and_lymphoid_tissueBlood/Lymphatic Systemhttps://doi.org/10.1093/nar/gkaa945
G250Ehaematopoietic_neoplasm_haematopoietic_and_lymphoid_tissueBlood/Lymphatic Systemhttps://doi.org/10.1093/nar/gkaa945
G250Elymphoid_neoplasm_haematopoietic_and_lymphoid_tissueBlood/Lymphatic Systemhttps://doi.org/10.1093/nar/gkaa945
G250Ecarcinoma_lungLunghttps://doi.org/10.1093/nar/gkaa945
H396Plymphoid_neoplasm_haematopoietic_and_lymphoid_tissueBlood/Lymphatic Systemhttps://doi.org/10.1093/nar/gkaa945
H396Phaematopoietic_neoplasm_haematopoietic_and_lymphoid_tissueBlood/Lymphatic Systemhttps://doi.org/10.1093/nar/gkaa945
M351Thaematopoietic_neoplasm_haematopoietic_and_lymphoid_tissueBlood/Lymphatic Systemhttps://doi.org/10.1093/nar/gkaa945
Q252Hhaematopoietic_neoplasm_haematopoietic_and_lymphoid_tissueBlood/Lymphatic Systemhttps://doi.org/10.1093/nar/gkaa945
T315Ihaematopoietic_neoplasm_haematopoietic_and_lymphoid_tissueBlood/Lymphatic Systemhttps://doi.org/10.1093/nar/gkaa945
T315Ilymphoid_neoplasm_haematopoietic_and_lymphoid_tissueBlood/Lymphatic Systemhttps://doi.org/10.1093/nar/gkaa945
T315Imalignant_melanoma_skinSkinhttps://doi.org/10.1093/nar/gkaa945
T315Iadnexal_tumour_skinSkinhttps://doi.org/10.1093/nar/gkaa945
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