Midostaurin — dose-response

MeasuredDerived

Dose-response curves across the assayed kinome. ← All drugs

Midostaurin × RPS6KA6

MeasuredDerived

IC50

7.74 nM

Hill slope

1.10

R²

1.0000

Top kinases by potency

MeasuredDerived

Ordered by IC50 ascending (fitted).

Kinase	IC50
JAK3	1.75 nM
FLT3	3.51 nM
MAP3K9	3.53 nM
RPS6KA6	7.74 nM
SIK2	7.95 nM
MAP3K11	10.02 nM
RPS6KA2	10.25 nM
MAP3K10	10.25 nM
SIK1	10.55 nM
PHKG1	12.82 nM
STK4	13.10 nM
TNK1	13.44 nM
STK3	13.65 nM
RPS6KA3	14.70 nM
PDPK1	14.79 nM
DDR1	14.85 nM
AURKA	15.79 nM
NTRK3	17.06 nM
MAP4K3	17.85 nM
MARK4	17.96 nM
RPS6KA1	20.60 nM
NTRK1	20.81 nM
PRKG2	21.32 nM
TBK1	21.83 nM
MARK2	22.79 nM
AURKB	24.03 nM
NUAK1	24.10 nM
BRSK2	24.23 nM
MELK	25.99 nM
CSF1R	26.63 nM