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ADRBK2(GRK3)

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UniProt P35626 · PDB · AlphaFold · Substrate: Casein · Clone: full-length

Top inhibitors

#DrugInhibitionResidualKISSGini
1Netarsudil23.2%76.8%93.220.676
2Gilteritinib18.9%81.1%88.970.506
3Abrocitinib11.0%89.0%99.500.581
4Ponatinib9.2%90.8%78.230.534
5Ceritinib8.9%91.1%95.440.618
6Fedratinib7.7%92.3%96.210.576
7Asciminib7.1%92.9%100.000.602
8Mobocertinib6.1%93.9%97.220.757
9Tivozanib6.0%94.0%92.420.673
10Brigatinib6.0%94.0%82.960.513
11Capivasertib5.5%94.5%96.480.644
12Crizotinib5.1%94.9%91.390.581
13Sorafenib4.6%95.4%96.720.776
14Pemigatinib4.6%95.4%98.230.718
15Fostamatinib3.9%96.1%96.740.613
16Lenvatinib3.7%96.3%97.740.726
17Tepotinib3.7%96.3%99.750.727
18Tucatinib3.6%96.4%99.750.652
19Ruxolitinib3.2%96.8%98.250.592
20Capmatinib3.2%96.8%99.750.582

Paralog block

No paralog group registered for this kinase.

EMT expression

Not in the EMT expression panel.

Selectivity landscape vs inhibition on ADRBK2

Each point is one of the 92 approved drugs; color = inhibition % on ADRBK2.

3D structure

Embedded NGL viewer pulls a representative PDB entry (or AlphaFold model if no experimental structure is registered). Heavy bundle — loaded only on demand.

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