UniProt P51451 · PDB · AlphaFold · Substrate: pEY · Clone: full-length
Top inhibitors
| # | Drug | Inhibition | Residual | KISS | Gini |
|---|---|---|---|---|---|
| 1 | Dasatinib | 100.0% | 0.0% | 87.97 | 0.699 |
| 2 | Ponatinib | 100.0% | 0.0% | 78.23 | 0.534 |
| 3 | Bosutinib | 100.0% | 0.0% | 87.22 | 0.555 |
| 4 | Ibrutinib | 99.7% | 0.3% | 94.74 | 0.723 |
| 5 | Canertinib | 99.7% | 0.3% | 96.49 | 0.671 |
| 6 | Mobocertinib | 99.7% | 0.3% | 97.22 | 0.757 |
| 7 | Zanubrutinib | 99.1% | 0.9% | 98.24 | 0.788 |
| 8 | Lazertinib | 99.0% | 1.0% | 97.47 | 0.674 |
| 9 | Repotrectinib | 98.4% | 1.6% | 84.21 | 0.608 |
| 10 | Neratinib | 98.2% | 1.8% | 93.18 | 0.597 |
| 11 | Nintedanib | 97.6% | 2.4% | 90.23 | 0.608 |
| 12 | Afatinib | 96.8% | 3.2% | 98.50 | 0.709 |
| 13 | Pralsetinib | 96.1% | 3.9% | 93.43 | 0.643 |
| 14 | Dacomitinib | 94.5% | 5.5% | 97.99 | 0.664 |
| 15 | Tivozanib | 94.2% | 5.8% | 92.42 | 0.673 |
| 16 | Vandetanib | 92.8% | 7.2% | 95.74 | 0.723 |
| 17 | Brigatinib | 92.3% | 7.7% | 82.96 | 0.513 |
| 18 | Gilteritinib | 92.3% | 7.7% | 88.97 | 0.506 |
| 19 | Cabozantinib | 91.6% | 8.4% | 92.73 | 0.751 |
| 20 | Osimertinib | 90.0% | 9.9% | 97.24 | 0.733 |
Paralog block
No paralog group registered for this kinase.
EMT expression
- Mesenchymal log2(TPM+1): 0.36
- Epithelial log2(TPM+1): 0.31
- Fold change: 0.04
- Status: No significant change
Selectivity landscape vs inhibition on BLK
Each point is one of the 92 approved drugs; color = inhibition % on BLK.
3D structure
Embedded NGL viewer pulls a representative PDB entry (or AlphaFold model if no experimental structure is registered). Heavy bundle — loaded only on demand.
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