CDK8/CCNC(CDK8/cyclin C)
Sign in to save this workspaceUniProt CDK8: P49336; cyclin C: P24863 · PDB · AlphaFold (P49336), AlphaFold (P24863) · Substrate: Pol2-CTD · Clone: full length / full length
Top inhibitors
| # | Drug | Inhibition | Residual | KISS | Gini |
|---|---|---|---|---|---|
| 1 | Midostaurin | 89.0% | 11.0% | 78.64 | 0.500 |
| 2 | Brigatinib | 87.0% | 13.0% | 82.96 | 0.513 |
| 3 | Sunitinib | 83.1% | 16.9% | 91.73 | 0.524 |
| 4 | Abemaciclib | 77.3% | 22.7% | 91.48 | 0.563 |
| 5 | Alectinib | 75.3% | 24.7% | 95.49 | 0.651 |
| 6 | Bosutinib | 73.3% | 26.7% | 87.22 | 0.555 |
| 7 | Baricitinib | 70.0% | 30.0% | 97.99 | 0.616 |
| 8 | Ruxolitinib | 69.0% | 31.0% | 98.25 | 0.592 |
| 9 | Nintedanib | 68.1% | 31.9% | 90.23 | 0.608 |
| 10 | Gilteritinib | 66.2% | 33.8% | 88.97 | 0.506 |
| 11 | Ribociclib | 55.6% | 44.4% | 99.25 | 0.729 |
| 12 | Palbociclib | 48.8% | 51.2% | 98.75 | 0.673 |
| 13 | Lorlatinib | 40.2% | 59.8% | 97.24 | 0.694 |
| 14 | Axitinib | 29.1% | 70.9% | 93.23 | 0.688 |
| 15 | Capivasertib | 28.7% | 71.3% | 96.48 | 0.644 |
| 16 | Gefitinib | 28.2% | 71.8% | 99.25 | 0.650 |
| 17 | Osimertinib | 21.6% | 78.4% | 97.24 | 0.733 |
| 18 | Afatinib | 17.6% | 82.4% | 98.50 | 0.709 |
| 19 | Netarsudil | 16.4% | 83.6% | 93.22 | 0.676 |
| 20 | Vandetanib | 16.0% | 84.0% | 95.74 | 0.723 |
Paralog block
No paralog group registered for this kinase.
EMT expression
Not in the EMT expression panel.
Selectivity landscape vs inhibition on CDK8/CCNC
Each point is one of the 92 approved drugs; color = inhibition % on CDK8/CCNC.
3D structure
Embedded NGL viewer pulls a representative PDB entry (or AlphaFold model if no experimental structure is registered). Heavy bundle — loaded only on demand.
Annotations
Sign in to read and post annotations.
Loading…