UniProt P06241 · PDB · AlphaFold · Substrate: pEY · Clone: full-length
Top inhibitors
| # | Drug | Inhibition | Residual | KISS | Gini |
|---|---|---|---|---|---|
| 1 | Dasatinib | 100.0% | 0.0% | 87.97 | 0.699 |
| 2 | Bosutinib | 99.7% | 0.3% | 87.22 | 0.555 |
| 3 | Ponatinib | 99.4% | 0.6% | 78.23 | 0.534 |
| 4 | Repotrectinib | 97.1% | 2.9% | 84.21 | 0.608 |
| 5 | Nintedanib | 95.6% | 4.4% | 90.23 | 0.608 |
| 6 | Pacritinib | 92.2% | 7.8% | 88.64 | 0.452 |
| 7 | Ibrutinib | 92.1% | 7.9% | 94.74 | 0.723 |
| 8 | Gilteritinib | 85.9% | 14.1% | 88.97 | 0.506 |
| 9 | Ripretinib | 84.0% | 16.0% | 92.95 | 0.674 |
| 10 | Fedratinib | 83.5% | 16.5% | 96.21 | 0.576 |
| 11 | Entrectinib | 82.0% | 17.9% | 93.69 | 0.671 |
| 12 | Vandetanib | 75.6% | 24.4% | 95.74 | 0.723 |
| 13 | Brigatinib | 73.9% | 26.1% | 82.96 | 0.513 |
| 14 | Midostaurin | 69.9% | 30.1% | 78.64 | 0.500 |
| 15 | Tivozanib | 67.5% | 32.5% | 92.42 | 0.673 |
| 16 | Neratinib | 66.0% | 34.0% | 93.18 | 0.597 |
| 17 | Canertinib | 61.4% | 38.6% | 96.49 | 0.671 |
| 18 | Pirtobrutinib | 58.1% | 41.9% | 99.49 | 0.656 |
| 19 | Vemurafenib | 54.7% | 45.3% | 96.49 | 0.598 |
| 20 | Crizotinib | 53.3% | 46.7% | 91.39 | 0.581 |
Paralog block
No paralog group registered for this kinase.
EMT expression
- Mesenchymal log2(TPM+1): 5.29
- Epithelial log2(TPM+1): 3.44
- Fold change: 1.85
- Status: Upregulated
Selectivity landscape vs inhibition on FYN
Each point is one of the 92 approved drugs; color = inhibition % on FYN.
Mutation lollipop
Cancer-associated mutations plotted by residue position. Marker size + color scale with the number of distinct cancer reports.
Variants (1)
Mutation × cancer associations
| Mutation | Cancer | Organ | Source |
|---|---|---|---|
| Y531F | AML-US | Blood/Lymphatic System | ref |
| Y531F | glioma_central_nervous_system | Brain/CNS | ref |
3D structure
Embedded NGL viewer pulls a representative PDB entry (or AlphaFold model if no experimental structure is registered). Heavy bundle — loaded only on demand.
Annotations
Sign in to read and post annotations.
Loading…