UniProt Q08881 · PDB · AlphaFold · Substrate: MBP · Clone: full-length
Top inhibitors
| # | Drug | Inhibition | Residual | KISS | Gini |
|---|---|---|---|---|---|
| 1 | Canertinib | 96.9% | 3.1% | 96.49 | 0.671 |
| 2 | Ibrutinib | 94.5% | 5.5% | 94.74 | 0.723 |
| 3 | Mobocertinib | 94.4% | 5.6% | 97.22 | 0.757 |
| 4 | Repotrectinib | 88.0% | 12.0% | 84.21 | 0.608 |
| 5 | Osimertinib | 85.4% | 14.6% | 97.24 | 0.733 |
| 6 | Lazertinib | 84.0% | 16.0% | 97.47 | 0.674 |
| 7 | Neratinib | 78.4% | 21.6% | 93.18 | 0.597 |
| 8 | Zanubrutinib | 74.5% | 25.4% | 98.24 | 0.788 |
| 9 | Dacomitinib | 73.6% | 26.4% | 97.99 | 0.664 |
| 10 | Entrectinib | 68.4% | 31.6% | 93.69 | 0.671 |
| 11 | Afatinib | 58.7% | 41.3% | 98.50 | 0.709 |
| 12 | Nintedanib | 51.9% | 48.1% | 90.23 | 0.608 |
| 13 | Ponatinib | 38.8% | 61.2% | 78.23 | 0.534 |
| 14 | Brigatinib | 36.6% | 63.4% | 82.96 | 0.513 |
| 15 | Sunitinib | 35.2% | 64.8% | 91.73 | 0.524 |
| 16 | Pacritinib | 25.9% | 74.1% | 88.64 | 0.452 |
| 17 | Defactinib | 25.3% | 74.7% | 92.68 | 0.450 |
| 18 | Trametinib | 24.4% | 75.6% | 99.50 | 0.718 |
| 19 | Fostamatinib | 24.2% | 75.8% | 96.74 | 0.613 |
| 20 | Gilteritinib | 20.2% | 79.8% | 88.97 | 0.506 |
Paralog block
No paralog group registered for this kinase.
EMT expression
- Mesenchymal log2(TPM+1): 0.15
- Epithelial log2(TPM+1): 0.06
- Fold change: 0.09
- Status: No significant change
Selectivity landscape vs inhibition on ITK
Each point is one of the 92 approved drugs; color = inhibition % on ITK.
3D structure
Embedded NGL viewer pulls a representative PDB entry (or AlphaFold model if no experimental structure is registered). Heavy bundle — loaded only on demand.
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