MP2K3(MEK3)
Sign in to save this workspaceUniProt P46734 · PDB · AlphaFold · Substrate: p38a (K53A) · Clone: full-length (1-347end)
Top inhibitors
| # | Drug | Inhibition | Residual | KISS | Gini |
|---|---|---|---|---|---|
| 1 | Pralsetinib | 68.2% | 31.8% | 93.43 | 0.643 |
| 2 | Gilteritinib | 53.8% | 46.2% | 88.97 | 0.506 |
| 3 | Defactinib | 35.2% | 64.8% | 92.68 | 0.450 |
| 4 | Abemaciclib | 31.2% | 68.8% | 91.48 | 0.563 |
| 5 | Encorafenib | 29.5% | 70.5% | 98.50 | 0.755 |
| 6 | Acalabrutinib | 24.2% | 75.8% | 99.50 | 0.670 |
| 7 | Capivasertib | 18.0% | 82.0% | 96.48 | 0.644 |
| 8 | Ceritinib | 15.8% | 84.2% | 95.44 | 0.618 |
| 9 | Lenvatinib | 11.7% | 88.3% | 97.74 | 0.726 |
| 10 | Vemurafenib | 11.3% | 88.7% | 96.49 | 0.598 |
| 11 | Ibrutinib | 10.9% | 89.1% | 94.74 | 0.723 |
| 12 | Brigatinib | 10.0% | 90.0% | 82.96 | 0.513 |
| 13 | Mitapivat | 9.3% | 90.7% | 100.00 | 0.625 |
| 14 | Vandetanib | 8.4% | 91.6% | 95.74 | 0.723 |
| 15 | Remibrutinib | 8.4% | 91.6% | 99.50 | 0.721 |
| 16 | Pemigatinib | 8.0% | 92.0% | 98.23 | 0.718 |
| 17 | Zanubrutinib | 7.2% | 92.8% | 98.24 | 0.788 |
| 18 | Avapritinib | 7.1% | 92.9% | 97.73 | 0.644 |
| 19 | Asciminib | 7.1% | 92.9% | 100.00 | 0.602 |
| 20 | Pirtobrutinib | 5.6% | 94.4% | 99.49 | 0.656 |
Paralog block
No paralog group registered for this kinase.
EMT expression
Not in the EMT expression panel.
Selectivity landscape vs inhibition on MP2K3
Each point is one of the 92 approved drugs; color = inhibition % on MP2K3.
3D structure
Embedded NGL viewer pulls a representative PDB entry (or AlphaFold model if no experimental structure is registered). Heavy bundle — loaded only on demand.
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