MET(c-MET)
Sign in to save this workspaceUniProt P08581 · PDB · AlphaFold · Substrate: pEY · Clone: aa 956-1390
Top inhibitors
| # | Drug | Inhibition | Residual | KISS | Gini |
|---|
Paralog block
No paralog group registered for this kinase.
EMT expression
- Mesenchymal log2(TPM+1): 5.26
- Epithelial log2(TPM+1): 4.06
- Fold change: 1.20
- Status: Upregulated
Selectivity landscape vs inhibition on MET
Each point is one of the 92 approved drugs; color = inhibition % on MET.
Variants (29)
c-MET (D1213H)
point
c-MET (D1228A)
point
c-MET (D1228G)
point
c-MET (D1228H)
point
c-MET (D1228N)
point
c-MET (D1228V)
point
c-MET (D1228Y)
point
c-MET (Del Ex14)
point
c-MET (F1200I)
point
c-MET (G1163R)
point
c-MET (H1094L)
point
c-MET (H1094Y)
point
c-MET (K1244R)
point
c-MET (L1195F)
point
c-MET (L1195V)
point
c-MET (M1250I)
point
c-MET (M1250T)
point
c-MET (P991S)
point
c-MET (R1227K)
point
c-MET (R970C)
point
c-MET (T1173I)
point
c-MET (T992I)
point
c-MET (V1092I)
point
c-MET (Y1230A)
point
c-MET (Y1230C)
point
c-MET (Y1230D)
point
c-MET (Y1230H)
point
c-MET (Y1230S)
point
c-MET (Y1235D)
point
3D structure
Embedded NGL viewer pulls a representative PDB entry (or AlphaFold model if no experimental structure is registered). Heavy bundle — loaded only on demand.
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