c-MET (D1213H)
Sign in to save this workspaceMET · Variant type: point · HGVS: p.D1213H
Drug response on this variant
| # | Drug | Inhibition on variant | Residual | KISS |
|---|---|---|---|---|
| 1 | Gilteritinib | 81.5% | 18.5% | 88.97 |
| 2 | Repotrectinib | 33.5% | 66.5% | 84.21 |
| 3 | Abemaciclib | 25.7% | 74.3% | 91.48 |
| 4 | Canertinib | 22.5% | 77.5% | 96.49 |
| 5 | Sunitinib | 10.1% | 89.9% | 91.73 |
| 6 | Inavolisib | 9.3% | 90.7% | 100.00 |
| 7 | Cobimetinib | 2.5% | 97.5% | 100.00 |
| 8 | Erlotinib | 1.9% | 98.1% | 99.75 |
| 9 | Darovasertib | 1.8% | 98.2% | 96.99 |
| 10 | Acalabrutinib | 1.6% | 98.4% | 99.50 |
| 11 | Remibrutinib | 1.6% | 98.4% | 99.50 |
| 12 | Capivasertib | 0.0% | 100.0% | 96.48 |
| 13 | Palbociclib | 0.0% | 100.0% | 98.75 |
| 14 | Vandetanib | 0.0% | 100.0% | 95.74 |
| 15 | Quizartinib | 0.0% | 100.0% | 99.50 |
Wild-type vs variant — drug response delta
Positive Δ means the drug hits the variant harder than wild-type (mutation-selective); negative Δ means it loses potency (resistance).
| Drug | Variant inh | WT inh | Δ (variant − WT) |
|---|---|---|---|
| Gilteritinib | 81.5% | — | — |
| Repotrectinib | 33.5% | — | — |
| Abemaciclib | 25.7% | — | — |
| Canertinib | 22.5% | — | — |
| Sunitinib | 10.1% | — | — |
| Inavolisib | 9.3% | — | — |
| Cobimetinib | 2.5% | — | — |
| Erlotinib | 1.9% | — | — |
| Darovasertib | 1.8% | — | — |
| Acalabrutinib | 1.6% | — | — |
| Remibrutinib | 1.6% | — | — |
| Capivasertib | 0.0% | — | — |
| Palbociclib | 0.0% | — | — |
| Vandetanib | 0.0% | — | — |
| Quizartinib | 0.0% | — | — |
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