UniProt Q99640 · PDB · AlphaFold · Substrate: MBP · Clone: full length
Top inhibitors
| # | Drug | Inhibition | Residual | KISS | Gini |
|---|---|---|---|---|---|
| 1 | Abemaciclib | 79.9% | 20.1% | 91.48 | 0.563 |
| 2 | Alectinib | 67.2% | 32.8% | 95.49 | 0.651 |
| 3 | Gilteritinib | 61.1% | 38.9% | 88.97 | 0.506 |
| 4 | Palbociclib | 60.5% | 39.5% | 98.75 | 0.673 |
| 5 | Midostaurin | 58.6% | 41.4% | 78.64 | 0.500 |
| 6 | Sunitinib | 54.9% | 45.1% | 91.73 | 0.524 |
| 7 | Vemurafenib | 49.4% | 50.6% | 96.49 | 0.598 |
| 8 | Nintedanib | 47.0% | 53.0% | 90.23 | 0.608 |
| 9 | Bosutinib | 44.3% | 55.7% | 87.22 | 0.555 |
| 10 | Baricitinib | 40.9% | 59.1% | 97.99 | 0.616 |
| 11 | Ruxolitinib | 40.3% | 59.7% | 98.25 | 0.592 |
| 12 | Regorafenib | 40.0% | 60.0% | 95.99 | 0.719 |
| 13 | Netarsudil | 37.4% | 62.6% | 93.22 | 0.676 |
| 14 | Afatinib | 37.0% | 63.0% | 98.50 | 0.709 |
| 15 | Axitinib | 36.2% | 63.8% | 93.23 | 0.688 |
| 16 | Nilotinib | 35.5% | 64.5% | 96.49 | 0.765 |
| 17 | Everolimus | 33.8% | 66.2% | 100.00 | 0.706 |
| 18 | Dasatinib | 32.2% | 67.8% | 87.97 | 0.699 |
| 19 | Lapatinib | 31.1% | 68.9% | 99.25 | 0.616 |
| 20 | Gefitinib | 31.0% | 69.0% | 99.25 | 0.650 |
Paralog block
No paralog group registered for this kinase.
EMT expression
- Mesenchymal log2(TPM+1): 4.46
- Epithelial log2(TPM+1): 5.27
- Fold change: -0.81
- Status: No significant change
Selectivity landscape vs inhibition on PKMYT1
Each point is one of the 92 approved drugs; color = inhibition % on PKMYT1.
3D structure
Embedded NGL viewer pulls a representative PDB entry (or AlphaFold model if no experimental structure is registered). Heavy bundle — loaded only on demand.
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