UniProt Q9HBY8 · PDB · AlphaFold · Substrate: Crosstide · Clone: full length (Met1-Cys367)
Top inhibitors
| # | Drug | Inhibition | Residual | KISS | Gini |
|---|---|---|---|---|---|
| 1 | Abemaciclib | 57.7% | 42.3% | 91.48 | 0.563 |
| 2 | Netarsudil | 57.3% | 42.7% | 93.22 | 0.676 |
| 3 | Sunitinib | 29.3% | 70.7% | 91.73 | 0.524 |
| 4 | Capivasertib | 27.8% | 72.2% | 96.48 | 0.644 |
| 5 | Darovasertib | 27.4% | 72.6% | 96.99 | 0.719 |
| 6 | Remibrutinib | 22.5% | 77.5% | 99.50 | 0.721 |
| 7 | Gilteritinib | 19.9% | 80.1% | 88.97 | 0.506 |
| 8 | Pacritinib | 19.5% | 80.5% | 88.64 | 0.452 |
| 9 | Inavolisib | 16.2% | 83.8% | 100.00 | 0.679 |
| 10 | Vemurafenib | 13.7% | 86.3% | 96.49 | 0.598 |
| 11 | Lenvatinib | 12.2% | 87.8% | 97.74 | 0.726 |
| 12 | Sirolimus | 12.2% | 87.8% | 100.00 | 0.708 |
| 13 | Dasatinib | 12.1% | 87.9% | 87.97 | 0.699 |
| 14 | Midostaurin | 11.8% | 88.2% | 78.64 | 0.500 |
| 15 | Selpercatinib | 11.2% | 88.8% | 96.72 | 0.635 |
| 16 | Encorafenib | 10.8% | 89.2% | 98.50 | 0.755 |
| 17 | Pemigatinib | 10.5% | 89.5% | 98.23 | 0.718 |
| 18 | Neratinib | 10.4% | 89.6% | 93.18 | 0.597 |
| 19 | Regorafenib | 10.2% | 89.8% | 95.99 | 0.719 |
| 20 | Gefitinib | 9.6% | 90.4% | 99.25 | 0.650 |
Paralog block
No paralog group registered for this kinase.
EMT expression
- Mesenchymal log2(TPM+1): 0.39
- Epithelial log2(TPM+1): 1.58
- Fold change: -1.20
- Status: Downregulated
Selectivity landscape vs inhibition on SGK2
Each point is one of the 92 approved drugs; color = inhibition % on SGK2.
3D structure
Embedded NGL viewer pulls a representative PDB entry (or AlphaFold model if no experimental structure is registered). Heavy bundle — loaded only on demand.
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