UniProt Q9NRH2 · PDB · AlphaFold · Substrate: MBP · Clone: full-length
Top inhibitors
| # | Drug | Inhibition | Residual | KISS | Gini |
|---|---|---|---|---|---|
| 1 | Ceritinib | 51.0% | 49.0% | 95.44 | 0.618 |
| 2 | Gedatolisib | 17.0% | 83.0% | 99.75 | 0.611 |
| 3 | Mobocertinib | 16.6% | 83.4% | 97.22 | 0.757 |
| 4 | Lazertinib | 16.0% | 84.0% | 97.47 | 0.674 |
| 5 | Abrocitinib | 14.4% | 85.6% | 99.50 | 0.581 |
| 6 | Avapritinib | 14.2% | 85.8% | 97.73 | 0.644 |
| 7 | Pirtobrutinib | 12.6% | 87.4% | 99.49 | 0.656 |
| 8 | Tepotinib | 11.6% | 88.4% | 99.75 | 0.727 |
| 9 | Tenalisib | 10.3% | 89.7% | 97.98 | 0.702 |
| 10 | Capmatinib | 10.3% | 89.7% | 99.75 | 0.582 |
| 11 | Neratinib | 9.9% | 90.1% | 93.18 | 0.597 |
| 12 | Fedratinib | 9.8% | 90.2% | 96.21 | 0.576 |
| 13 | Zanubrutinib | 9.8% | 90.2% | 98.24 | 0.788 |
| 14 | Mitapivat | 9.0% | 91.0% | 100.00 | 0.625 |
| 15 | Brigatinib | 8.3% | 91.7% | 82.96 | 0.513 |
| 16 | Ribociclib | 7.9% | 92.1% | 99.25 | 0.729 |
| 17 | Upadacitinib | 6.8% | 93.2% | 97.98 | 0.663 |
| 18 | Tucatinib | 6.7% | 93.3% | 99.75 | 0.652 |
| 19 | Sunitinib | 6.6% | 93.4% | 91.73 | 0.524 |
| 20 | Palbociclib | 6.5% | 93.5% | 98.75 | 0.673 |
Paralog block
No paralog group registered for this kinase.
EMT expression
- Mesenchymal log2(TPM+1): 2.84
- Epithelial log2(TPM+1): 2.61
- Fold change: 0.22
- Status: No significant change
Selectivity landscape vs inhibition on SNRK
Each point is one of the 92 approved drugs; color = inhibition % on SNRK.
3D structure
Embedded NGL viewer pulls a representative PDB entry (or AlphaFold model if no experimental structure is registered). Heavy bundle — loaded only on demand.
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