UniProt Q9UKI8 · PDB · AlphaFold · Substrate: Histone H3 · Clone: full-length
Top inhibitors
| # | Drug | Inhibition | Residual | KISS | Gini |
|---|---|---|---|---|---|
| 1 | Bosutinib | 42.0% | 58.0% | 87.22 | 0.555 |
| 2 | Defactinib | 38.5% | 61.5% | 92.68 | 0.450 |
| 3 | Lapatinib | 25.0% | 75.0% | 99.25 | 0.616 |
| 4 | Midostaurin | 22.8% | 77.2% | 78.64 | 0.500 |
| 5 | Pacritinib | 22.0% | 78.0% | 88.64 | 0.452 |
| 6 | Ponatinib | 19.8% | 80.2% | 78.23 | 0.534 |
| 7 | Gilteritinib | 19.6% | 80.4% | 88.97 | 0.506 |
| 8 | Ceritinib | 17.8% | 82.2% | 95.44 | 0.618 |
| 9 | Mobocertinib | 16.7% | 83.3% | 97.22 | 0.757 |
| 10 | Neratinib | 16.2% | 83.8% | 93.18 | 0.597 |
| 11 | Pirtobrutinib | 15.3% | 84.7% | 99.49 | 0.656 |
| 12 | Tenalisib | 15.0% | 85.0% | 97.98 | 0.702 |
| 13 | Lazertinib | 14.9% | 85.1% | 97.47 | 0.674 |
| 14 | Capmatinib | 14.7% | 85.3% | 99.75 | 0.582 |
| 15 | Crizotinib | 13.9% | 86.1% | 91.39 | 0.581 |
| 16 | Sunitinib | 13.5% | 86.5% | 91.73 | 0.524 |
| 17 | Gedatolisib | 13.2% | 86.8% | 99.75 | 0.611 |
| 18 | Netarsudil | 12.9% | 87.1% | 93.22 | 0.676 |
| 19 | Leniolisib | 12.6% | 87.4% | 100.00 | 0.604 |
| 20 | Cobimetinib | 12.6% | 87.4% | 100.00 | 0.644 |
Paralog block
No paralog group registered for this kinase.
EMT expression
- Mesenchymal log2(TPM+1): 4.08
- Epithelial log2(TPM+1): 4.08
- Fold change: -0.00
- Status: No significant change
Selectivity landscape vs inhibition on TLK1
Each point is one of the 92 approved drugs; color = inhibition % on TLK1.
3D structure
Embedded NGL viewer pulls a representative PDB entry (or AlphaFold model if no experimental structure is registered). Heavy bundle — loaded only on demand.
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