UniProt Q86Y07 · PDB · AlphaFold · Substrate: Casein + Mn · Clone: aa 1-375
Top inhibitors
| # | Drug | Inhibition | Residual | KISS | Gini |
|---|---|---|---|---|---|
| 1 | Defactinib | 31.4% | 68.6% | 92.68 | 0.450 |
| 2 | Bosutinib | 31.3% | 68.7% | 87.22 | 0.555 |
| 3 | Lorlatinib | 19.8% | 80.2% | 97.24 | 0.694 |
| 4 | Ripretinib | 14.9% | 85.1% | 92.95 | 0.674 |
| 5 | Binimetinib | 13.3% | 86.7% | 100.00 | 0.689 |
| 6 | Pirtobrutinib | 11.8% | 88.2% | 99.49 | 0.656 |
| 7 | Pazopanib | 9.5% | 90.5% | 97.49 | 0.672 |
| 8 | Selumetinib | 9.2% | 90.8% | 100.00 | 0.640 |
| 9 | Rabusertib | 8.4% | 91.6% | 98.74 | 0.687 |
| 10 | Dasatinib | 8.3% | 91.7% | 87.97 | 0.699 |
| 11 | Netarsudil | 8.2% | 91.8% | 93.22 | 0.676 |
| 12 | Deucravacitinib | 8.0% | 92.0% | 98.99 | 0.718 |
| 13 | Mitapivat | 7.6% | 92.4% | 100.00 | 0.625 |
| 14 | Zanubrutinib | 7.1% | 92.9% | 98.24 | 0.788 |
| 15 | Erdafitinib | 6.8% | 93.2% | 95.71 | 0.737 |
| 16 | Erlotinib | 6.7% | 93.3% | 99.75 | 0.695 |
| 17 | Neratinib | 6.7% | 93.3% | 93.18 | 0.597 |
| 18 | Avapritinib | 6.3% | 93.7% | 97.73 | 0.644 |
| 19 | Abemaciclib | 6.3% | 93.7% | 91.48 | 0.563 |
| 20 | Abrocitinib | 6.2% | 93.8% | 99.50 | 0.581 |
Paralog block
No paralog group registered for this kinase.
EMT expression
- Mesenchymal log2(TPM+1): 3.77
- Epithelial log2(TPM+1): 4.01
- Fold change: -0.24
- Status: No significant change
Selectivity landscape vs inhibition on VRK2
Each point is one of the 92 approved drugs; color = inhibition % on VRK2.
3D structure
Embedded NGL viewer pulls a representative PDB entry (or AlphaFold model if no experimental structure is registered). Heavy bundle — loaded only on demand.
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