SRR1444580
GTEX
Clinical attributes
From the source cohort, normalized into canonical keys plus the project's native columns.
- cancer_type
- GTEX
- cancer_type_detailed
- —
- subtype
- —
- cancer_type
- GTEX
- sex
- Male
GSVA pathway preview (50 Hallmark scores)
Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.
Top 10 elevated
- OXIDATIVE_PHOSPHORYLATION+0.368
- KRAS_SIGNALING_DN+0.299
- REACTIVE_OXYGEN_SPECIES_PATHWAY+0.290
- HEDGEHOG_SIGNALING+0.272
- SPERMATOGENESIS+0.257
- MYOGENESIS+0.230
- PANCREAS_BETA_CELLS+0.157
- FATTY_ACID_METABOLISM+0.120
- BILE_ACID_METABOLISM+0.109
- APICAL_SURFACE+0.076
Top 10 suppressed
- IL6_JAK_STAT3_SIGNALING-0.605
- ALLOGRAFT_REJECTION-0.508
- E2F_TARGETS-0.495
- G2M_CHECKPOINT-0.480
- INFLAMMATORY_RESPONSE-0.477
- INTERFERON_GAMMA_RESPONSE-0.474
- INTERFERON_ALPHA_RESPONSE-0.467
- TNFA_SIGNALING_VIA_NFKB-0.460
- MYC_TARGETS_V1-0.423
- EPITHELIAL_MESENCHYMAL_TRANSITION-0.394
Patient twins — nearest pathway neighbors
10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.
10 twins match this tumor's tissue · 0 come from a different tissue of origin
| # | Sample | Cancer type | Subtype | cos similarity |
|---|---|---|---|---|
| 1 | SRR1440986 | GTEX | — | 0.980 |
| 2 | SRR1082262 | GTEX | — | 0.967 |
| 3 | SRR1356619 | GTEX | — | 0.965 |
| 4 | SRR1416434 | GTEX | — | 0.965 |
| 5 | SRR1434526 | GTEX | — | 0.964 |
| 6 | SRR1353176 | GTEX | — | 0.963 |
| 7 | SRR1391769 | GTEX | — | 0.963 |
| 8 | SRR1333930 | GTEX | — | 0.958 |
| 9 | SRR1323746 | GTEX | — | 0.958 |
| 10 | SRR1401424 | GTEX | — | 0.957 |
Per-pathway drug coverage
For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.
0 of 11 elevated pathways have at least one drug that meaningfully reverses them.
| Pathway (elevated) | tumor score | Best drug | reversal magnitude |
|---|---|---|---|
| OXIDATIVE_PHOSPHORYLATION | 0.368 | Remibrutinib | — uncovered |
| KRAS_SIGNALING_DN | 0.299 | Remibrutinib | — uncovered |
| REACTIVE_OXYGEN_SPECIES_PATHWAY | 0.290 | Inavolisib | — uncovered |
| HEDGEHOG_SIGNALING | 0.272 | Inavolisib | — uncovered |
| SPERMATOGENESIS | 0.257 | Inavolisib | — uncovered |
| MYOGENESIS | 0.230 | Inavolisib | — uncovered |
| PANCREAS_BETA_CELLS | 0.157 | Cobimetinib | — uncovered |
| FATTY_ACID_METABOLISM | 0.120 | Inavolisib | — uncovered |
| BILE_ACID_METABOLISM | 0.109 | Inavolisib | — uncovered |
| APICAL_SURFACE | 0.076 | Temsirolimus | — uncovered |
| APICAL_JUNCTION | 0.067 | Inavolisib | — uncovered |