Research Use Only. KIRhub outputs are computational research artifacts. They are not validated for clinical decision-making, diagnosis, or treatment.

← Cohorts · medullo-epn-umap@date-based

SJEPD006_D.RNA-Seq

EPN · Supratentorial EPN

01b1eba4-f6c8-58d7-9620-9fe6cb9d3b9f

Score in workbench →

Clinical attributes

From the source cohort, normalized into canonical keys plus the project's native columns.

cancer_type
EPN
cancer_type_detailed
—
subtype
Supratentorial EPN
cancer_type
EPN
subtype
Supratentorial EPN
age_years
13.13
fusion
ZFTA_RELA
e1_e2
E1
umap1_2d
-3.293507649
umap2_2d
-0.022407654
umap1_3d
1.152161879
umap2_3d
2.958651123
umap3_3d
-1.839959071
dataset
EPN-StJude

GSVA pathway preview (50 Hallmark scores)

MeasuredDerivedReference

Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.

Top 10 elevated

  • MYOGENESIS+0.390
  • INTERFERON_ALPHA_RESPONSE+0.350
  • APICAL_SURFACE+0.300
  • PANCREAS_BETA_CELLS+0.300
  • KRAS_SIGNALING_DN+0.270
  • INTERFERON_GAMMA_RESPONSE+0.260
  • ALLOGRAFT_REJECTION+0.230
  • COAGULATION+0.220
  • P53_PATHWAY+0.190
  • INFLAMMATORY_RESPONSE+0.170

Top 10 suppressed

  • E2F_TARGETS-0.560
  • G2M_CHECKPOINT-0.560
  • MYC_TARGETS_V1-0.520
  • PROTEIN_SECRETION-0.490
  • MITOTIC_SPINDLE-0.450
  • UV_RESPONSE_DN-0.450
  • ANDROGEN_RESPONSE-0.430
  • UNFOLDED_PROTEIN_RESPONSE-0.420
  • TGF_BETA_SIGNALING-0.330
  • NOTCH_SIGNALING-0.310

Patient twins — nearest pathway neighbors

MeasuredDerived

10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.

8 twins match this tumor's tissue · 2 come from a different tissue of origin

#SampleCancer typeSubtypecos similarity
1TCGA-E7-A519-01A-11R-A26T-07
bladder-landscape@3
——0.915
2SJEPD017_D.RNA-Seq
medullo-epn-umap@date-based
EPNSupratentorial EPN0.880
3SJEPD040_D.RNA-Seq
medullo-epn-umap@date-based
EPNSupratentorial EPN0.870
4SJEPD001532_R1.RNA-Seq
medullo-epn-umap@date-based
EPNSupratentorial EPN0.863
5SRR1473654
brain-umap@2
GTEX—0.863
6TCGA-A2-A3XW-01A-11R-A239-07
breast-umap@18
—B0.859
7TCGA-WT-AB41-01A-11R-A41B-07
breast-umap@18
—B0.858
8SJEPD001523_R1.RNA-Seq
medullo-epn-umap@date-based
EPNPosterior Fossa EPN0.858
9MDT-AP-0437
medullo-epn-umap@date-based
MedMedulloblastoma0.856
10SJEPD012_D.RNA-Seq
medullo-epn-umap@date-based
EPNPosterior Fossa EPN0.856

Per-pathway drug coverage

ModeledCalibratedDerived

For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.

0 of 22 elevated pathways have at least one drug that meaningfully reverses them.

Pathway (elevated)tumor scoreBest drugreversal magnitude
MYOGENESIS0.390Inavolisib— uncovered
INTERFERON_ALPHA_RESPONSE0.350Inavolisib— uncovered
APICAL_SURFACE0.300Temsirolimus— uncovered
PANCREAS_BETA_CELLS0.300Cobimetinib— uncovered
KRAS_SIGNALING_DN0.270Remibrutinib— uncovered
INTERFERON_GAMMA_RESPONSE0.260Idelalisib— uncovered
ALLOGRAFT_REJECTION0.230Idelalisib— uncovered
COAGULATION0.220Binimetinib— uncovered
P53_PATHWAY0.190Idelalisib— uncovered
INFLAMMATORY_RESPONSE0.170Idelalisib— uncovered
IL6_JAK_STAT3_SIGNALING0.140Inavolisib— uncovered
XENOBIOTIC_METABOLISM0.120Inavolisib— uncovered
REACTIVE_OXYGEN_SPECIES_PATHWAY0.090Inavolisib— uncovered
ANGIOGENESIS0.080Remibrutinib— uncovered
IL2_STAT5_SIGNALING0.080Idelalisib— uncovered
KRAS_SIGNALING_UP0.080Inavolisib— uncovered
APICAL_JUNCTION0.070Inavolisib— uncovered
BILE_ACID_METABOLISM0.060Inavolisib— uncovered
UV_RESPONSE_UP0.050Idelalisib— uncovered
APOPTOSIS0.030Idelalisib— uncovered