MBCProject_0063_T1_RNA
— · C
Clinical attributes
From the source cohort, normalized into canonical keys plus the project's native columns.
- cancer_type
- —
- cancer_type_detailed
- —
- subtype
- C
- subtype
- C
GSVA pathway preview (50 Hallmark scores)
Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.
Top 10 elevated
- PANCREAS_BETA_CELLS+0.370
- EPITHELIAL_MESENCHYMAL_TRANSITION+0.240
- HEDGEHOG_SIGNALING+0.210
- UNFOLDED_PROTEIN_RESPONSE+0.150
- GLYCOLYSIS+0.120
- MYC_TARGETS_V1+0.050
- UV_RESPONSE_DN+0.050
- ANGIOGENESIS+0.020
- PEROXISOME+0.020
- NOTCH_SIGNALING-0.010
Top 10 suppressed
- INTERFERON_ALPHA_RESPONSE-0.600
- INTERFERON_GAMMA_RESPONSE-0.550
- IL6_JAK_STAT3_SIGNALING-0.510
- ALLOGRAFT_REJECTION-0.500
- E2F_TARGETS-0.470
- TNFA_SIGNALING_VIA_NFKB-0.450
- INFLAMMATORY_RESPONSE-0.420
- COMPLEMENT-0.410
- MITOTIC_SPINDLE-0.390
- G2M_CHECKPOINT-0.380
Patient twins — nearest pathway neighbors
10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.
10 twins match this tumor's tissue · 0 come from a different tissue of origin
| # | Sample | Cancer type | Subtype | cos similarity |
|---|---|---|---|---|
| 1 | TCGA-A7-A0D9-01A-31R-A056-07 | — | B | 0.844 |
| 2 | TCGA-UF-A7JA-01A-12R-A34R-07 | — | — | 0.837 |
| 3 | SRR25617868 | — | B | 0.830 |
| 4 | TCGA-B6-A0RN-01A-12R-A084-07 | — | B | 0.825 |
| 5 | 204241b7-1e28-43f8-a681-f872b52fa3f8 | — | — | 0.820 |
| 6 | ca7940e6-af7e-44fd-a6fc-5d86dc1d86c4 | — | — | 0.818 |
| 7 | TCGA-CN-A49A-01A-11R-A24H-07 | — | — | 0.813 |
| 8 | MNG1289 | — | — | 0.813 |
| 9 | TCGA-CV-7424-01A-11R-2081-07 | — | — | 0.808 |
| 10 | SRR8518202 | — | A | 0.806 |
Per-pathway drug coverage
For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.
0 of 9 elevated pathways have at least one drug that meaningfully reverses them.
| Pathway (elevated) | tumor score | Best drug | reversal magnitude |
|---|---|---|---|
| PANCREAS_BETA_CELLS | 0.370 | Cobimetinib | — uncovered |
| EPITHELIAL_MESENCHYMAL_TRANSITION | 0.240 | Inavolisib | — uncovered |
| HEDGEHOG_SIGNALING | 0.210 | Inavolisib | — uncovered |
| UNFOLDED_PROTEIN_RESPONSE | 0.150 | Idelalisib | — uncovered |
| GLYCOLYSIS | 0.120 | Inavolisib | — uncovered |
| MYC_TARGETS_V1 | 0.050 | Inavolisib | — uncovered |
| UV_RESPONSE_DN | 0.050 | Inavolisib | — uncovered |
| ANGIOGENESIS | 0.020 | Remibrutinib | — uncovered |
| PEROXISOME | 0.020 | Idelalisib | — uncovered |