MNG1074
—
Clinical attributes
From the source cohort, normalized into canonical keys plus the project's native columns.
- cancer_type
- —
- cancer_type_detailed
- —
- subtype
- —
GSVA pathway preview (50 Hallmark scores)
Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.
Top 10 elevated
- PROTEIN_SECRETION+0.427
- TNFA_SIGNALING_VIA_NFKB+0.418
- ANDROGEN_RESPONSE+0.278
- MTORC1_SIGNALING+0.275
- UNFOLDED_PROTEIN_RESPONSE+0.252
- INTERFERON_ALPHA_RESPONSE+0.238
- HEME_METABOLISM+0.228
- NOTCH_SIGNALING+0.226
- MITOTIC_SPINDLE+0.224
- PEROXISOME+0.217
Top 10 suppressed
- MYOGENESIS-0.314
- EPITHELIAL_MESENCHYMAL_TRANSITION-0.257
- HEDGEHOG_SIGNALING-0.222
- PANCREAS_BETA_CELLS-0.169
- KRAS_SIGNALING_DN-0.131
- ALLOGRAFT_REJECTION-0.114
- E2F_TARGETS-0.064
- APICAL_SURFACE-0.057
- XENOBIOTIC_METABOLISM-0.041
- CHOLESTEROL_HOMEOSTASIS-0.034
Patient twins — nearest pathway neighbors
10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.
9 twins match this tumor's tissue · 1 come from a different tissue of origin
| # | Sample | Cancer type | Subtype | cos similarity |
|---|---|---|---|---|
| 1 | MNG928 | — | — | 0.802 |
| 2 | 33060001-05C9-4751-AA58-F194207ACC08 | — | — | 0.790 |
| 3 | A235537D-BF50-4796-B01A-FAD83EFDAD25 | — | — | 0.779 |
| 4 | MNG319 | — | — | 0.766 |
| 5 | 8C34CD93-1AC0-4920-9E72-439EED0CF85D | — | — | 0.766 |
| 6 | SRR6013491 | — | cohortA1 | 0.763 |
| 7 | SRR5903550 | — | cohortA4 | 0.757 |
| 8 | 5EC64886-2295-497A-BEE8-8AA17D8DADF1 | — | — | 0.740 |
| 9 | R315 | — | — | 0.733 |
| 10 | BS_XF0ZX2B3 | Supratentorial Ependymoma | — | 0.728 |
Per-pathway drug coverage
For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.
0 of 38 elevated pathways have at least one drug that meaningfully reverses them.
| Pathway (elevated) | tumor score | Best drug | reversal magnitude |
|---|---|---|---|
| PROTEIN_SECRETION | 0.427 | Remibrutinib | — uncovered |
| TNFA_SIGNALING_VIA_NFKB | 0.418 | Inavolisib | — uncovered |
| ANDROGEN_RESPONSE | 0.278 | Inavolisib | — uncovered |
| MTORC1_SIGNALING | 0.275 | Inavolisib | — uncovered |
| UNFOLDED_PROTEIN_RESPONSE | 0.252 | Idelalisib | — uncovered |
| INTERFERON_ALPHA_RESPONSE | 0.238 | Inavolisib | — uncovered |
| HEME_METABOLISM | 0.228 | Temsirolimus | — uncovered |
| NOTCH_SIGNALING | 0.226 | Inavolisib | — uncovered |
| MITOTIC_SPINDLE | 0.224 | Inavolisib | — uncovered |
| PEROXISOME | 0.217 | Idelalisib | — uncovered |
| HYPOXIA | 0.213 | Idelalisib | — uncovered |
| P53_PATHWAY | 0.200 | Idelalisib | — uncovered |
| MYC_TARGETS_V1 | 0.196 | Inavolisib | — uncovered |
| TGF_BETA_SIGNALING | 0.184 | Inavolisib | — uncovered |
| FATTY_ACID_METABOLISM | 0.181 | Inavolisib | — uncovered |
| INFLAMMATORY_RESPONSE | 0.173 | Idelalisib | — uncovered |
| IL6_JAK_STAT3_SIGNALING | 0.155 | Inavolisib | — uncovered |
| MYC_TARGETS_V2 | 0.155 | Idelalisib | — uncovered |
| UV_RESPONSE_UP | 0.145 | Idelalisib | — uncovered |
| INTERFERON_GAMMA_RESPONSE | 0.140 | Idelalisib | — uncovered |