5566453e-df41-4aab-8dd0-825efbece954
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Clinical attributes
From the source cohort, normalized into canonical keys plus the project's native columns.
- cancer_type
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- cancer_type_detailed
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- subtype
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GSVA pathway preview (50 Hallmark scores)
Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.
Top 10 elevated
- INTERFERON_ALPHA_RESPONSE+0.800
- INTERFERON_GAMMA_RESPONSE+0.700
- ALLOGRAFT_REJECTION+0.600
- IL6_JAK_STAT3_SIGNALING+0.600
- INFLAMMATORY_RESPONSE+0.500
- COMPLEMENT+0.400
- TNFA_SIGNALING_VIA_NFKB+0.400
- APICAL_SURFACE+0.200
- APOPTOSIS+0.200
- IL2_STAT5_SIGNALING+0.200
Top 10 suppressed
- EPITHELIAL_MESENCHYMAL_TRANSITION-0.500
- ANGIOGENESIS-0.400
- MYC_TARGETS_V2-0.400
- E2F_TARGETS-0.300
- G2M_CHECKPOINT-0.300
- MYC_TARGETS_V1-0.300
- MYOGENESIS-0.300
- ADIPOGENESIS-0.200
- ANDROGEN_RESPONSE-0.200
- APICAL_JUNCTION-0.200
Patient twins — nearest pathway neighbors
10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.
10 twins match this tumor's tissue · 0 come from a different tissue of origin
| # | Sample | Cancer type | Subtype | cos similarity |
|---|---|---|---|---|
| 1 | ERR2208965 | — | — | 0.900 |
| 2 | SRR8518215 | — | D | 0.876 |
| 3 | TCGA-62-A46U-01A-11R-A24H-07 | — | cohortA1 | 0.871 |
| 4 | ff12dc45-d7ab-45ae-a049-2d20e3c546b6 | — | — | 0.857 |
| 5 | TCGA-S3-AA17-01A-11R-A41B-07 | — | D | 0.857 |
| 6 | 94b2af92-0cfc-40b2-977d-6bd0fa4440d9 | — | — | 0.856 |
| 7 | 20090401.Her2HRpos | — | D | 0.856 |
| 8 | SRR8613763 | — | D | 0.856 |
| 9 | 3a2b80a5-6937-423a-92bf-9e25a0b23c5b | — | — | 0.855 |
| 10 | SRR8518387 | — | D | 0.846 |
Per-pathway drug coverage
For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.
0 of 15 elevated pathways have at least one drug that meaningfully reverses them.
| Pathway (elevated) | tumor score | Best drug | reversal magnitude |
|---|---|---|---|
| INTERFERON_ALPHA_RESPONSE | 0.800 | Inavolisib | — uncovered |
| INTERFERON_GAMMA_RESPONSE | 0.700 | Idelalisib | — uncovered |
| ALLOGRAFT_REJECTION | 0.600 | Idelalisib | — uncovered |
| IL6_JAK_STAT3_SIGNALING | 0.600 | Inavolisib | — uncovered |
| INFLAMMATORY_RESPONSE | 0.500 | Idelalisib | — uncovered |
| COMPLEMENT | 0.400 | Inavolisib | — uncovered |
| TNFA_SIGNALING_VIA_NFKB | 0.400 | Inavolisib | — uncovered |
| APICAL_SURFACE | 0.200 | Temsirolimus | — uncovered |
| APOPTOSIS | 0.200 | Idelalisib | — uncovered |
| IL2_STAT5_SIGNALING | 0.200 | Idelalisib | — uncovered |
| KRAS_SIGNALING_UP | 0.200 | Inavolisib | — uncovered |
| BILE_ACID_METABOLISM | 0.100 | Inavolisib | — uncovered |
| P53_PATHWAY | 0.100 | Idelalisib | — uncovered |
| PI3K_AKT_MTOR_SIGNALING | 0.100 | Inavolisib | — uncovered |
| REACTIVE_OXYGEN_SPECIES_PATHWAY | 0.100 | Inavolisib | — uncovered |