SRR12475139

—

041f588e-7cfb-5210-8d82-4ee84c6d4bdf

Score in workbench →

Clinical attributes

From the source cohort, normalized into canonical keys plus the project's native columns.

cancer_type: —
cancer_type_detailed: —
subtype: —

GSVA pathway preview (0 Hallmark scores)

MeasuredDerivedReference

Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.

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Patient twins — nearest pathway neighbors

MeasuredDerived

10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.

10 twins match this tumor's tissue · 0 come from a different tissue of origin

#	Sample	Cancer type	Subtype	cos similarity
1	SRR12475121 colon-landscapes@1	—	—	0.927
2	SRR17866835 colon-landscapes@1	—	—	0.922
3	0429cf04-6e5c-41dd-b4a9-4f7ad15d15bc colon-landscapes@1	—	—	0.884
4	SRR12475112 colon-landscapes@1	—	—	0.878
5	SRR12475115 colon-landscapes@1	—	—	0.860
6	SRR12475148 colon-landscapes@1	—	—	0.847
7	TCGA-55-7284-01B-11R-2241-07 lung-landscapes@6	—	cohortA1	0.846
8	TCGA-97-7552-01A-11R-2039-07 lung-landscapes@6	—	cohortA1	0.846
9	SRR17866825 colon-landscapes@1	—	—	0.844
10	TCGA-91-7771-01A-11R-2170-07 lung-landscapes@6	—	cohortA2	0.841

Per-pathway drug coverage

ModeledCalibratedDerived

For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.

0 of 26 elevated pathways have at least one drug that meaningfully reverses them.

Pathway (elevated)	tumor score	Best drug	reversal magnitude
PROTEIN_SECRETION	0.430	Remibrutinib	— uncovered
INTERFERON_ALPHA_RESPONSE	0.370	Inavolisib	— uncovered
TGF_BETA_SIGNALING	0.330	Inavolisib	— uncovered
INTERFERON_GAMMA_RESPONSE	0.320	Idelalisib	— uncovered
HEME_METABOLISM	0.300	Temsirolimus	— uncovered
COMPLEMENT	0.280	Inavolisib	— uncovered
IL6_JAK_STAT3_SIGNALING	0.280	Inavolisib	— uncovered
ANDROGEN_RESPONSE	0.260	Inavolisib	— uncovered
INFLAMMATORY_RESPONSE	0.250	Idelalisib	— uncovered
PI3K_AKT_MTOR_SIGNALING	0.250	Inavolisib	— uncovered
TNFA_SIGNALING_VIA_NFKB	0.220	Inavolisib	— uncovered
UV_RESPONSE_DN	0.210	Inavolisib	— uncovered
PANCREAS_BETA_CELLS	0.160	Cobimetinib	— uncovered
HYPOXIA	0.150	Idelalisib	— uncovered
APOPTOSIS	0.100	Idelalisib	— uncovered
IL2_STAT5_SIGNALING	0.100	Idelalisib	— uncovered
KRAS_SIGNALING_UP	0.100	Inavolisib	— uncovered
ALLOGRAFT_REJECTION	0.080	Idelalisib	— uncovered
BILE_ACID_METABOLISM	0.080	Inavolisib	— uncovered
MYOGENESIS	0.080	Inavolisib	— uncovered