SRR598196
GTEX
Clinical attributes
From the source cohort, normalized into canonical keys plus the project's native columns.
- cancer_type
- GTEX
- cancer_type_detailed
- —
- subtype
- —
- cancer_type
- GTEX
- sex
- Female
GSVA pathway preview (50 Hallmark scores)
Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.
Top 10 elevated
- OXIDATIVE_PHOSPHORYLATION+0.246
- MYOGENESIS+0.226
- REACTIVE_OXYGEN_SPECIES_PATHWAY+0.216
- SPERMATOGENESIS+0.188
- PEROXISOME+0.173
- HEDGEHOG_SIGNALING+0.172
- FATTY_ACID_METABOLISM+0.163
- INTERFERON_ALPHA_RESPONSE+0.152
- XENOBIOTIC_METABOLISM+0.108
- HEME_METABOLISM+0.106
Top 10 suppressed
- MYC_TARGETS_V1-0.465
- G2M_CHECKPOINT-0.442
- E2F_TARGETS-0.434
- ANGIOGENESIS-0.393
- MTORC1_SIGNALING-0.383
- TNFA_SIGNALING_VIA_NFKB-0.378
- UNFOLDED_PROTEIN_RESPONSE-0.374
- MYC_TARGETS_V2-0.308
- DNA_REPAIR-0.305
- PROTEIN_SECRETION-0.292
Patient twins — nearest pathway neighbors
10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.
10 twins match this tumor's tissue · 0 come from a different tissue of origin
| # | Sample | Cancer type | Subtype | cos similarity |
|---|---|---|---|---|
| 1 | SRR613438 | GTEX | — | 0.906 |
| 2 | SRR612380 | GTEX | — | 0.894 |
| 3 | SRR1486626 | GTEX | — | 0.885 |
| 4 | SRR1452447 | GTEX | — | 0.872 |
| 5 | SRR1314767 | GTEX | — | 0.863 |
| 6 | SRR612899 | GTEX | — | 0.859 |
| 7 | SRR1434934 | GTEX | — | 0.852 |
| 8 | SRR1324043 | GTEX | — | 0.849 |
| 9 | SRR615838 | GTEX | — | 0.845 |
| 10 | SRR1076072 | GTEX | — | 0.843 |
Per-pathway drug coverage
For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.
0 of 18 elevated pathways have at least one drug that meaningfully reverses them.
| Pathway (elevated) | tumor score | Best drug | reversal magnitude |
|---|---|---|---|
| OXIDATIVE_PHOSPHORYLATION | 0.246 | Remibrutinib | — uncovered |
| MYOGENESIS | 0.226 | Inavolisib | — uncovered |
| REACTIVE_OXYGEN_SPECIES_PATHWAY | 0.216 | Inavolisib | — uncovered |
| SPERMATOGENESIS | 0.188 | Inavolisib | — uncovered |
| PEROXISOME | 0.173 | Idelalisib | — uncovered |
| HEDGEHOG_SIGNALING | 0.172 | Inavolisib | — uncovered |
| FATTY_ACID_METABOLISM | 0.163 | Inavolisib | — uncovered |
| INTERFERON_ALPHA_RESPONSE | 0.152 | Inavolisib | — uncovered |
| XENOBIOTIC_METABOLISM | 0.108 | Inavolisib | — uncovered |
| HEME_METABOLISM | 0.106 | Temsirolimus | — uncovered |
| ADIPOGENESIS | 0.105 | Inavolisib | — uncovered |
| BILE_ACID_METABOLISM | 0.095 | Inavolisib | — uncovered |
| KRAS_SIGNALING_DN | 0.086 | Remibrutinib | — uncovered |
| ESTROGEN_RESPONSE_EARLY | 0.082 | Inavolisib | — uncovered |
| APICAL_JUNCTION | 0.079 | Inavolisib | — uncovered |
| APICAL_SURFACE | 0.064 | Temsirolimus | — uncovered |
| ESTROGEN_RESPONSE_LATE | 0.054 | Idelalisib | — uncovered |
| UV_RESPONSE_DN | 0.009 | Inavolisib | — uncovered |