Research Use Only. KIRhub outputs are computational research artifacts. They are not validated for clinical decision-making, diagnosis, or treatment.

SRR934886

08dacd57-45ad-5e75-81e9-8dfcf2ea4b6d

Score in workbench →

Clinical attributes

From the source cohort, normalized into canonical keys plus the project's native columns.

cancer_type
cancer_type_detailed
subtype
sex
Female

GSVA pathway preview (0 Hallmark scores)

MeasuredDerivedReference

Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.

No GSVA scores available for this sample.

Patient twins — nearest pathway neighbors

MeasuredDerived

10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.

10 twins match this tumor's tissue · 0 come from a different tissue of origin

#SampleCancer typeSubtypecos similarity
1SRR934760
brain-umap@2
0.938
2SRR934881
brain-umap@2
0.922
3SRR934962
brain-umap@2
0.910
4SRR934868
brain-umap@2
0.891
5SRR934753
brain-umap@2
0.889
618E8E3EF-B708-4618-8C89-2F5A9A6A2C9D
brain-umap@2
0.887
7SRR934956
brain-umap@2
0.877
8SRR934934
brain-umap@2
0.876
9SRR934864
brain-umap@2
0.873
10TCGA-70-6722-01A-11R-1820-07
lung-landscapes@6
cohortSQ10.870

Per-pathway drug coverage

ModeledCalibratedDerived

For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.

0 of 36 elevated pathways have at least one drug that meaningfully reverses them.

Pathway (elevated)tumor scoreBest drugreversal magnitude
ANGIOGENESIS0.570Remibrutinib— uncovered
EPITHELIAL_MESENCHYMAL_TRANSITION0.513Inavolisib— uncovered
G2M_CHECKPOINT0.510Inavolisib— uncovered
E2F_TARGETS0.480Inavolisib— uncovered
MYC_TARGETS_V10.423Inavolisib— uncovered
WNT_BETA_CATENIN_SIGNALING0.374Inavolisib— uncovered
TGF_BETA_SIGNALING0.365Inavolisib— uncovered
INTERFERON_GAMMA_RESPONSE0.356Idelalisib— uncovered
APOPTOSIS0.337Idelalisib— uncovered
UNFOLDED_PROTEIN_RESPONSE0.337Idelalisib— uncovered
ALLOGRAFT_REJECTION0.305Idelalisib— uncovered
NOTCH_SIGNALING0.305Inavolisib— uncovered
ANDROGEN_RESPONSE0.300Inavolisib— uncovered
IL6_JAK_STAT3_SIGNALING0.289Inavolisib— uncovered
TNFA_SIGNALING_VIA_NFKB0.286Inavolisib— uncovered
IL2_STAT5_SIGNALING0.274Idelalisib— uncovered
HEDGEHOG_SIGNALING0.273Inavolisib— uncovered
MITOTIC_SPINDLE0.270Inavolisib— uncovered
INTERFERON_ALPHA_RESPONSE0.261Inavolisib— uncovered
MYC_TARGETS_V20.256Idelalisib— uncovered