MNG1245
—
Clinical attributes
From the source cohort, normalized into canonical keys plus the project's native columns.
- cancer_type
- —
- cancer_type_detailed
- —
- subtype
- —
GSVA pathway preview (50 Hallmark scores)
Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.
Top 10 elevated
- ALLOGRAFT_REJECTION+0.316
- KRAS_SIGNALING_DN+0.276
- HEDGEHOG_SIGNALING+0.237
- MYOGENESIS+0.223
- PANCREAS_BETA_CELLS+0.202
- EPITHELIAL_MESENCHYMAL_TRANSITION+0.156
- APICAL_JUNCTION+0.108
- IL6_JAK_STAT3_SIGNALING+0.095
- KRAS_SIGNALING_UP+0.090
- INTERFERON_GAMMA_RESPONSE+0.084
Top 10 suppressed
- PROTEIN_SECRETION-0.541
- G2M_CHECKPOINT-0.495
- MYC_TARGETS_V1-0.495
- E2F_TARGETS-0.485
- MTORC1_SIGNALING-0.479
- OXIDATIVE_PHOSPHORYLATION-0.418
- UNFOLDED_PROTEIN_RESPONSE-0.389
- DNA_REPAIR-0.369
- CHOLESTEROL_HOMEOSTASIS-0.365
- UV_RESPONSE_DN-0.360
Patient twins — nearest pathway neighbors
10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.
6 twins match this tumor's tissue · 4 come from a different tissue of origin
| # | Sample | Cancer type | Subtype | cos similarity |
|---|---|---|---|---|
| 1 | MNG1159 | — | — | 0.941 |
| 2 | MNG1098 | — | — | 0.903 |
| 3 | MNG1148 | — | — | 0.902 |
| 4 | R96 | — | — | 0.901 |
| 5 | SRR1337431 | GTEX | — | 0.898 |
| 6 | SJEPD001533_D1.RNA-Seq | EPN | Posterior Fossa EPN | 0.897 |
| 7 | BS_77317DY4 | Med | Medulloblastoma | 0.891 |
| 8 | MNG436 | — | — | 0.886 |
| 9 | MNG1243 | — | — | 0.886 |
| 10 | BS_21RE8W46 | pilocytic astrocytoma | — | 0.883 |
Per-pathway drug coverage
For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.
0 of 13 elevated pathways have at least one drug that meaningfully reverses them.
| Pathway (elevated) | tumor score | Best drug | reversal magnitude |
|---|---|---|---|
| ALLOGRAFT_REJECTION | 0.316 | Idelalisib | — uncovered |
| KRAS_SIGNALING_DN | 0.276 | Remibrutinib | — uncovered |
| HEDGEHOG_SIGNALING | 0.237 | Inavolisib | — uncovered |
| MYOGENESIS | 0.223 | Inavolisib | — uncovered |
| PANCREAS_BETA_CELLS | 0.202 | Cobimetinib | — uncovered |
| EPITHELIAL_MESENCHYMAL_TRANSITION | 0.156 | Inavolisib | — uncovered |
| APICAL_JUNCTION | 0.108 | Inavolisib | — uncovered |
| IL6_JAK_STAT3_SIGNALING | 0.095 | Inavolisib | — uncovered |
| KRAS_SIGNALING_UP | 0.090 | Inavolisib | — uncovered |
| INTERFERON_GAMMA_RESPONSE | 0.084 | Idelalisib | — uncovered |
| COAGULATION | 0.061 | Binimetinib | — uncovered |
| INTERFERON_ALPHA_RESPONSE | 0.058 | Inavolisib | — uncovered |
| APICAL_SURFACE | 0.013 | Temsirolimus | — uncovered |