Research Use Only. KIRhub outputs are computational research artifacts. They are not validated for clinical decision-making, diagnosis, or treatment.

ERR4976617

· D

09803939-60a0-52dc-91ec-1b8623b107c6

Score in workbench →

Clinical attributes

From the source cohort, normalized into canonical keys plus the project's native columns.

cancer_type
cancer_type_detailed
subtype
D
subtype
D
overall_survival_months
112

GSVA pathway preview (50 Hallmark scores)

MeasuredDerivedReference

Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.

Top 10 elevated

  • INTERFERON_ALPHA_RESPONSE+0.600
  • INTERFERON_GAMMA_RESPONSE+0.500
  • ALLOGRAFT_REJECTION+0.490
  • IL6_JAK_STAT3_SIGNALING+0.410
  • COMPLEMENT+0.130
  • PANCREAS_BETA_CELLS+0.090
  • PI3K_AKT_MTOR_SIGNALING+0.080
  • INFLAMMATORY_RESPONSE+0.050
  • WNT_BETA_CATENIN_SIGNALING+0.050
  • HEME_METABOLISM+0.040

Top 10 suppressed

  • EPITHELIAL_MESENCHYMAL_TRANSITION-0.540
  • ESTROGEN_RESPONSE_EARLY-0.490
  • ESTROGEN_RESPONSE_LATE-0.490
  • ANGIOGENESIS-0.480
  • CHOLESTEROL_HOMEOSTASIS-0.480
  • MTORC1_SIGNALING-0.410
  • GLYCOLYSIS-0.400
  • HEDGEHOG_SIGNALING-0.370
  • OXIDATIVE_PHOSPHORYLATION-0.330
  • E2F_TARGETS-0.320

Patient twins — nearest pathway neighbors

MeasuredDerived

10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.

10 twins match this tumor's tissue · 0 come from a different tissue of origin

#SampleCancer typeSubtypecos similarity
1ERR4976618
breast-umap@18
D0.943
2MBCProject_1819_T2B_RNA
breast-umap@18
D0.905
3ERR2208899
melanoma-umap@29
0.895
4AUR-AG0J-TTP1-A-1-0-R-A741-41
breast-umap@18
D0.891
5SRR8518305
breast-umap@18
D0.877
6be8d8236-4ebc-46de-a4fd-a901fec1cdce
melanoma-umap@29
0.870
7TCGA-E9-A2JT-01A-22R-A18M-07
breast-umap@18
D0.869
8TCGA-AO-A0JC-01A-11R-A056-07
breast-umap@18
D0.868
9SRR1313132
breast-umap@18
D0.862
10s0122145
melanoma-umap@29
0.848

Per-pathway drug coverage

ModeledCalibratedDerived

For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.

0 of 10 elevated pathways have at least one drug that meaningfully reverses them.

Pathway (elevated)tumor scoreBest drugreversal magnitude
INTERFERON_ALPHA_RESPONSE0.600Inavolisib— uncovered
INTERFERON_GAMMA_RESPONSE0.500Idelalisib— uncovered
ALLOGRAFT_REJECTION0.490Idelalisib— uncovered
IL6_JAK_STAT3_SIGNALING0.410Inavolisib— uncovered
COMPLEMENT0.130Inavolisib— uncovered
PANCREAS_BETA_CELLS0.090Cobimetinib— uncovered
PI3K_AKT_MTOR_SIGNALING0.080Inavolisib— uncovered
INFLAMMATORY_RESPONSE0.050Idelalisib— uncovered
WNT_BETA_CATENIN_SIGNALING0.050Inavolisib— uncovered
HEME_METABOLISM0.040Temsirolimus— uncovered