Research Use Only. KIRhub outputs are computational research artifacts. They are not validated for clinical decision-making, diagnosis, or treatment.
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4FD9ED95-21E7-440D-AAA9-86DDDF12B37A

0ae83918-44fe-548b-a64a-00510aa328a0

Score in workbench →

Clinical attributes

From the source cohort, normalized into canonical keys plus the project's native columns.

cancer_type
cancer_type_detailed
subtype
overall_survival_months
21.38633377135348
age_years
51
sex
Female

GSVA pathway preview (0 Hallmark scores)

MeasuredDerivedReference

Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.

No GSVA scores available for this sample.

Patient twins — nearest pathway neighbors

MeasuredDerived

10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.

10 twins match this tumor's tissue · 0 come from a different tissue of origin

#SampleCancer typeSubtypecos similarity
1SRR934749
brain-umap@2
0.954
2CA366342-0949-4941-8AE6-984BAF032886
brain-umap@2
0.937
3SRR934880
brain-umap@2
0.936
4C6A16A8F-0AB7-42E9-A068-15EECF2912D3
brain-umap@2
0.933
54938761D-0762-4984-A399-BC036D6D2140
brain-umap@2
0.926
6293E6D35-8392-4C44-BC18-F917989516B0
brain-umap@2
0.920
70D1652B9-93F6-4D1A-BF06-B654663C92E3
brain-umap@2
0.919
874897E26-10A5-4484-A867-CE7C86DDB7E2
brain-umap@2
0.919
9SRR934879
brain-umap@2
0.917
10CEEF1D8C-DC91-4862-86A0-F345C2C770C0
brain-umap@2
0.908

Per-pathway drug coverage

ModeledCalibratedDerived

For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.

0 of 16 elevated pathways have at least one drug that meaningfully reverses them.

Pathway (elevated)tumor scoreBest drugreversal magnitude
MYC_TARGETS_V20.557Idelalisib— uncovered
MYC_TARGETS_V10.507Inavolisib— uncovered
E2F_TARGETS0.497Inavolisib— uncovered
G2M_CHECKPOINT0.488Inavolisib— uncovered
DNA_REPAIR0.421Idelalisib— uncovered
WNT_BETA_CATENIN_SIGNALING0.302Inavolisib— uncovered
PROTEIN_SECRETION0.292Remibrutinib— uncovered
MITOTIC_SPINDLE0.258Inavolisib— uncovered
UNFOLDED_PROTEIN_RESPONSE0.224Idelalisib— uncovered
NOTCH_SIGNALING0.172Inavolisib— uncovered
OXIDATIVE_PHOSPHORYLATION0.169Remibrutinib— uncovered
TGF_BETA_SIGNALING0.148Inavolisib— uncovered
HEDGEHOG_SIGNALING0.102Inavolisib— uncovered
ANGIOGENESIS0.022Remibrutinib— uncovered
PI3K_AKT_MTOR_SIGNALING0.016Inavolisib— uncovered
MTORC1_SIGNALING0.008Inavolisib— uncovered