BS_JZRM1S3T
medulloblastoma
Clinical attributes
From the source cohort, normalized into canonical keys plus the project's native columns.
- cancer_type
- medulloblastoma
- cancer_type_detailed
- —
- subtype
- —
- cancer_type
- medulloblastoma
- age_years
- 12.071
- sex
- Male
GSVA pathway preview (0 Hallmark scores)
Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.
Patient twins — nearest pathway neighbors
10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.
10 twins match this tumor's tissue · 0 come from a different tissue of origin
| # | Sample | Cancer type | Subtype | cos similarity |
|---|---|---|---|---|
| 1 | BS_YETBN0RQ | medulloblastoma | — | 0.970 |
| 2 | BS_4D9DD103 | medulloblastoma | — | 0.969 |
| 3 | BS_K3ER45RV | medulloblastoma | — | 0.963 |
| 4 | C3L-01285 | — | cohortSQ2 | 0.961 |
| 5 | BS_2Z1MKS84 | medulloblastoma | — | 0.957 |
| 6 | BS_GCQFGDTX | medulloblastoma | — | 0.956 |
| 7 | BS_HE57E1RP | medulloblastoma | — | 0.956 |
| 8 | BS_W644VEVE | medulloblastoma | — | 0.956 |
| 9 | BS_R439VVPK | medulloblastoma | — | 0.955 |
| 10 | BS_9NZ2D6AD | medulloblastoma | — | 0.955 |
Per-pathway drug coverage
For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.
0 of 14 elevated pathways have at least one drug that meaningfully reverses them.
| Pathway (elevated) | tumor score | Best drug | reversal magnitude |
|---|---|---|---|
| MYC_TARGETS_V2 | 0.679 | Idelalisib | — uncovered |
| E2F_TARGETS | 0.602 | Inavolisib | — uncovered |
| MYC_TARGETS_V1 | 0.583 | Inavolisib | — uncovered |
| G2M_CHECKPOINT | 0.545 | Inavolisib | — uncovered |
| DNA_REPAIR | 0.384 | Idelalisib | — uncovered |
| UNFOLDED_PROTEIN_RESPONSE | 0.315 | Idelalisib | — uncovered |
| PANCREAS_BETA_CELLS | 0.289 | Cobimetinib | — uncovered |
| SPERMATOGENESIS | 0.186 | Inavolisib | — uncovered |
| OXIDATIVE_PHOSPHORYLATION | 0.156 | Remibrutinib | — uncovered |
| WNT_BETA_CATENIN_SIGNALING | 0.108 | Inavolisib | — uncovered |
| MTORC1_SIGNALING | 0.072 | Inavolisib | — uncovered |
| MITOTIC_SPINDLE | 0.047 | Inavolisib | — uncovered |
| GLYCOLYSIS | 0.024 | Inavolisib | — uncovered |
| HEDGEHOG_SIGNALING | 0.016 | Inavolisib | — uncovered |