Research Use Only. KIRhub outputs are computational research artifacts. They are not validated for clinical decision-making, diagnosis, or treatment.

← Cohorts · breast-umap@18

GSM6454738

— · A

0cb0896d-e0b1-54c5-901d-438bd4b2f851

Score in workbench →

Clinical attributes

From the source cohort, normalized into canonical keys plus the project's native columns.

cancer_type
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cancer_type_detailed
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subtype
A
subtype
A

GSVA pathway preview (0 Hallmark scores)

MeasuredDerivedReference

Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.

No GSVA scores available for this sample.

Patient twins — nearest pathway neighbors

MeasuredDerived

10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.

10 twins match this tumor's tissue · 0 come from a different tissue of origin

#SampleCancer typeSubtypecos similarity
1TCGA-BH-A0DI-01A-21R-A12P-07
breast-umap@18
—A0.954
2SRR8518425
breast-umap@18
—A0.953
3TCGA-AN-A0FN-01A-11R-A034-07
breast-umap@18
—A0.942
4TCGA-E9-A1NG-01A-21R-A14M-07
breast-umap@18
—A0.941
5TCGA-46-3767-01A-01R-0980-07
lung-landscapes@6
—cohortSQ10.934
6TCGA-BH-A208-01A-11R-A157-07
breast-umap@18
—A0.933
7TCGA-A2-A0T6-01A-11R-A084-07
breast-umap@18
—A0.928
8TCGA-78-8648-01A-11R-2403-07
lung-landscapes@6
—cohortMD20.925
9cdb7b56c-ddca-4596-bfa2-6823c12837e2
colon-landscapes@1
——0.920
10TCGA-BH-A0DE-01A-11R-A115-07
breast-umap@18
—A0.920

Per-pathway drug coverage

ModeledCalibratedDerived

For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.

0 of 30 elevated pathways have at least one drug that meaningfully reverses them.

Pathway (elevated)tumor scoreBest drugreversal magnitude
EPITHELIAL_MESENCHYMAL_TRANSITION0.670Inavolisib— uncovered
ANGIOGENESIS0.610Remibrutinib— uncovered
UV_RESPONSE_DN0.520Inavolisib— uncovered
COAGULATION0.480Binimetinib— uncovered
INFLAMMATORY_RESPONSE0.470Idelalisib— uncovered
TGF_BETA_SIGNALING0.470Inavolisib— uncovered
TNFA_SIGNALING_VIA_NFKB0.470Inavolisib— uncovered
KRAS_SIGNALING_UP0.420Inavolisib— uncovered
IL6_JAK_STAT3_SIGNALING0.410Inavolisib— uncovered
APICAL_JUNCTION0.400Inavolisib— uncovered
COMPLEMENT0.400Inavolisib— uncovered
ALLOGRAFT_REJECTION0.370Idelalisib— uncovered
HEDGEHOG_SIGNALING0.350Inavolisib— uncovered
IL2_STAT5_SIGNALING0.340Idelalisib— uncovered
APICAL_SURFACE0.320Temsirolimus— uncovered
NOTCH_SIGNALING0.320Inavolisib— uncovered
MYOGENESIS0.290Inavolisib— uncovered
PANCREAS_BETA_CELLS0.250Cobimetinib— uncovered
APOPTOSIS0.240Idelalisib— uncovered
PROTEIN_SECRETION0.220Remibrutinib— uncovered