Research Use Only. KIRhub outputs are computational research artifacts. They are not validated for clinical decision-making, diagnosis, or treatment.

SRR934832

0e2ac580-6958-5544-9ebb-9f96fa3d50be

Score in workbench →

Clinical attributes

From the source cohort, normalized into canonical keys plus the project's native columns.

cancer_type
cancer_type_detailed
subtype
overall_survival_months
38.3377135348226
age_years
39
sex
Male

GSVA pathway preview (50 Hallmark scores)

MeasuredDerivedReference

Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.

Top 10 elevated

  • INTERFERON_ALPHA_RESPONSE+0.446
  • ALLOGRAFT_REJECTION+0.416
  • INTERFERON_GAMMA_RESPONSE+0.407
  • PROTEIN_SECRETION+0.384
  • MITOTIC_SPINDLE+0.379
  • IL6_JAK_STAT3_SIGNALING+0.359
  • COMPLEMENT+0.338
  • INFLAMMATORY_RESPONSE+0.319
  • TGF_BETA_SIGNALING+0.318
  • IL2_STAT5_SIGNALING+0.314

Top 10 suppressed

  • PANCREAS_BETA_CELLS-0.459
  • KRAS_SIGNALING_DN-0.328
  • OXIDATIVE_PHOSPHORYLATION-0.198
  • MYOGENESIS-0.177
  • SPERMATOGENESIS-0.148
  • HEDGEHOG_SIGNALING-0.139
  • MYC_TARGETS_V2-0.128
  • ESTROGEN_RESPONSE_LATE-0.053
  • DNA_REPAIR-0.048
  • ESTROGEN_RESPONSE_EARLY-0.025

Patient twins — nearest pathway neighbors

MeasuredDerived

10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.

10 twins match this tumor's tissue · 0 come from a different tissue of origin

#SampleCancer typeSubtypecos similarity
1SRR934830
brain-umap@2
0.928
2SRR934807
brain-umap@2
0.912
3738B9C39-A73F-4BD5-A8D4-3F75B9E14569
brain-umap@2
0.909
4SRR934942
brain-umap@2
0.909
5CB1F8B9C-7CE7-4181-B746-7FC697ED27F4
brain-umap@2
0.905
6722B7A0F-BF34-4368-8CFF-944FCBC7DAC4
brain-umap@2
0.899
7C1CCE12B-8892-49AB-8DF2-E5E280DEAE32
brain-umap@2
0.898
86292335B-7CBB-45BE-AA2A-B39FFDA8768D
brain-umap@2
0.898
9SRR934811
brain-umap@2
0.894
10E5FB107A-9555-419F-84BF-2A59873104B9
brain-umap@2
0.893

Per-pathway drug coverage

ModeledCalibratedDerived

For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.

0 of 36 elevated pathways have at least one drug that meaningfully reverses them.

Pathway (elevated)tumor scoreBest drugreversal magnitude
INTERFERON_ALPHA_RESPONSE0.446Inavolisib— uncovered
ALLOGRAFT_REJECTION0.416Idelalisib— uncovered
INTERFERON_GAMMA_RESPONSE0.407Idelalisib— uncovered
PROTEIN_SECRETION0.384Remibrutinib— uncovered
MITOTIC_SPINDLE0.379Inavolisib— uncovered
IL6_JAK_STAT3_SIGNALING0.359Inavolisib— uncovered
COMPLEMENT0.338Inavolisib— uncovered
INFLAMMATORY_RESPONSE0.319Idelalisib— uncovered
TGF_BETA_SIGNALING0.318Inavolisib— uncovered
IL2_STAT5_SIGNALING0.314Idelalisib— uncovered
TNFA_SIGNALING_VIA_NFKB0.306Inavolisib— uncovered
ANDROGEN_RESPONSE0.299Inavolisib— uncovered
G2M_CHECKPOINT0.295Inavolisib— uncovered
APOPTOSIS0.292Idelalisib— uncovered
PI3K_AKT_MTOR_SIGNALING0.241Inavolisib— uncovered
E2F_TARGETS0.231Inavolisib— uncovered
MTORC1_SIGNALING0.228Inavolisib— uncovered
COAGULATION0.218Binimetinib— uncovered
CHOLESTEROL_HOMEOSTASIS0.207Remibrutinib— uncovered
ADIPOGENESIS0.201Inavolisib— uncovered