Research Use Only. KIRhub outputs are computational research artifacts. They are not validated for clinical decision-making, diagnosis, or treatment.

TCGA-E2-A1II-01A-11R-A144-07

· E

0e8d9d27-f987-525f-a1c4-2c6163245615

Score in workbench →

Clinical attributes

From the source cohort, normalized into canonical keys plus the project's native columns.

cancer_type
cancer_type_detailed
subtype
E
subtype
E
overall_survival_months
34

GSVA pathway preview (0 Hallmark scores)

MeasuredDerivedReference

Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.

No GSVA scores available for this sample.

Patient twins — nearest pathway neighbors

MeasuredDerived

10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.

10 twins match this tumor's tissue · 0 come from a different tissue of origin

#SampleCancer typeSubtypecos similarity
1TCGA-BH-A209-01A-11R-A157-07
breast-umap@18
D0.923
220100125.TNBC
breast-umap@18
E0.922
3MBCproject_0095_T3_RNA
breast-umap@18
E0.914
4TCGA-AR-A0U0-01A-11R-A109-07
breast-umap@18
E0.903
5SRR8518297
breast-umap@18
E0.899
6MBCProject_5971_T1_RNA
breast-umap@18
D0.890
7TCGA-A2-A0EQ-01A-11R-A034-07
breast-umap@18
C0.889
8TCGA-AC-A6IW-01A-12R-A33J-07
breast-umap@18
E0.883
920060324.TNBC
breast-umap@18
D0.883
10c63f3f74-14fa-4a9e-9925-30b0f5da7dd9
colon-landscapes@1
0.883

Per-pathway drug coverage

ModeledCalibratedDerived

For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.

0 of 23 elevated pathways have at least one drug that meaningfully reverses them.

Pathway (elevated)tumor scoreBest drugreversal magnitude
MYC_TARGETS_V20.660Idelalisib— uncovered
ALLOGRAFT_REJECTION0.590Idelalisib— uncovered
INTERFERON_GAMMA_RESPONSE0.570Idelalisib— uncovered
INTERFERON_ALPHA_RESPONSE0.540Inavolisib— uncovered
E2F_TARGETS0.530Inavolisib— uncovered
MYC_TARGETS_V10.500Inavolisib— uncovered
G2M_CHECKPOINT0.440Inavolisib— uncovered
IL6_JAK_STAT3_SIGNALING0.430Inavolisib— uncovered
INFLAMMATORY_RESPONSE0.380Idelalisib— uncovered
MTORC1_SIGNALING0.310Inavolisib— uncovered
COMPLEMENT0.250Inavolisib— uncovered
DNA_REPAIR0.240Idelalisib— uncovered
REACTIVE_OXYGEN_SPECIES_PATHWAY0.240Inavolisib— uncovered
SPERMATOGENESIS0.230Inavolisib— uncovered
OXIDATIVE_PHOSPHORYLATION0.200Remibrutinib— uncovered
PI3K_AKT_MTOR_SIGNALING0.170Inavolisib— uncovered
UNFOLDED_PROTEIN_RESPONSE0.160Idelalisib— uncovered
IL2_STAT5_SIGNALING0.140Idelalisib— uncovered
MITOTIC_SPINDLE0.140Inavolisib— uncovered
UV_RESPONSE_UP0.120Idelalisib— uncovered