20050151.LumB
— · B
Clinical attributes
From the source cohort, normalized into canonical keys plus the project's native columns.
- cancer_type
- —
- cancer_type_detailed
- —
- subtype
- B
- subtype
- B
GSVA pathway preview (0 Hallmark scores)
Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.
Patient twins — nearest pathway neighbors
10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.
10 twins match this tumor's tissue · 0 come from a different tissue of origin
| # | Sample | Cancer type | Subtype | cos similarity |
|---|---|---|---|---|
| 1 | TCGA-B6-A0IC-01A-11R-A034-07 | — | B | 0.896 |
| 2 | TCGA-E2-A15K-06A-11R-A12P-07 | — | B | 0.895 |
| 3 | 20050053.LumB | — | B | 0.888 |
| 4 | 20120126.LumB | — | B | 0.867 |
| 5 | SRR35579806 | — | B | 0.863 |
| 6 | TCGA-A8-A09K-01A-11R-A00Z-07 | — | B | 0.856 |
| 7 | AUR-AFKB-TTM1-A-1-1-R-A742-41 | — | C | 0.853 |
| 8 | TCGA-E9-A5UO-01A-11R-A28M-07 | — | B | 0.849 |
| 9 | R320 | — | — | 0.849 |
| 10 | TCGA-E2-A1IE-01A-11R-A13Q-07 | — | B | 0.847 |
Per-pathway drug coverage
For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.
0 of 14 elevated pathways have at least one drug that meaningfully reverses them.
| Pathway (elevated) | tumor score | Best drug | reversal magnitude |
|---|---|---|---|
| ESTROGEN_RESPONSE_EARLY | 0.220 | Inavolisib | — uncovered |
| DNA_REPAIR | 0.200 | Idelalisib | — uncovered |
| E2F_TARGETS | 0.190 | Inavolisib | — uncovered |
| OXIDATIVE_PHOSPHORYLATION | 0.190 | Remibrutinib | — uncovered |
| G2M_CHECKPOINT | 0.160 | Inavolisib | — uncovered |
| PROTEIN_SECRETION | 0.160 | Remibrutinib | — uncovered |
| HEME_METABOLISM | 0.150 | Temsirolimus | — uncovered |
| MYC_TARGETS_V1 | 0.140 | Inavolisib | — uncovered |
| REACTIVE_OXYGEN_SPECIES_PATHWAY | 0.130 | Inavolisib | — uncovered |
| PEROXISOME | 0.110 | Idelalisib | — uncovered |
| ESTROGEN_RESPONSE_LATE | 0.100 | Idelalisib | — uncovered |
| MITOTIC_SPINDLE | 0.050 | Inavolisib | — uncovered |
| SPERMATOGENESIS | 0.030 | Inavolisib | — uncovered |
| TGF_BETA_SIGNALING | 0.020 | Inavolisib | — uncovered |