Research Use Only. KIRhub outputs are computational research artifacts. They are not validated for clinical decision-making, diagnosis, or treatment.

BS_13CGKADW

pilocytic astrocytoma

0fa1fad3-c681-56d4-83fc-49e6f1ae97b5

Score in workbench →

Clinical attributes

From the source cohort, normalized into canonical keys plus the project's native columns.

cancer_type
pilocytic astrocytoma
cancer_type_detailed
subtype
cancer_type
pilocytic astrocytoma
overall_survival_months
172.79894875164257
age_years
5.077
sex
Male

GSVA pathway preview (50 Hallmark scores)

MeasuredDerivedReference

Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.

Top 10 elevated

  • PROTEIN_SECRETION+0.341
  • ANDROGEN_RESPONSE+0.276
  • BILE_ACID_METABOLISM+0.257
  • MYOGENESIS+0.253
  • PANCREAS_BETA_CELLS+0.234
  • UV_RESPONSE_DN+0.228
  • REACTIVE_OXYGEN_SPECIES_PATHWAY+0.222
  • KRAS_SIGNALING_DN+0.220
  • ADIPOGENESIS+0.209
  • OXIDATIVE_PHOSPHORYLATION+0.198

Top 10 suppressed

  • MYC_TARGETS_V2-0.554
  • E2F_TARGETS-0.514
  • G2M_CHECKPOINT-0.479
  • DNA_REPAIR-0.435
  • WNT_BETA_CATENIN_SIGNALING-0.429
  • MYC_TARGETS_V1-0.397
  • ANGIOGENESIS-0.387
  • UNFOLDED_PROTEIN_RESPONSE-0.272
  • INTERFERON_ALPHA_RESPONSE-0.259
  • MITOTIC_SPINDLE-0.259

Patient twins — nearest pathway neighbors

MeasuredDerived

10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.

3 twins match this tumor's tissue · 7 come from a different tissue of origin ← cross-tissue dominant

#SampleCancer typeSubtypecos similarity
1BS_3PYESPHA
brain-umap@2
Ganglioglioma0.887
2BS_VMMJYN8Z
brain-umap@2
Ganglioglioma0.877
3BS_TMTV769C
brain-umap@2
low-grade glioma0.854
4SRR614563
brain-umap@2
GTEX0.843
5BS_ME3HKN2C
brain-umap@2
Ganglioglioma0.839
6BS_CGB2WS2A
brain-umap@2
pilocytic astrocytoma0.839
7BS_SFKZSJN1
brain-umap@2
low-grade glioma0.836
8SRR8518242
breast-umap@18
F0.833
9SRR1387264
brain-umap@2
GTEX0.822
10BS_ET8CJXSF
brain-umap@2
pilocytic astrocytoma0.815

Per-pathway drug coverage

ModeledCalibratedDerived

For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.

0 of 22 elevated pathways have at least one drug that meaningfully reverses them.

Pathway (elevated)tumor scoreBest drugreversal magnitude
PROTEIN_SECRETION0.341Remibrutinib— uncovered
ANDROGEN_RESPONSE0.276Inavolisib— uncovered
BILE_ACID_METABOLISM0.257Inavolisib— uncovered
MYOGENESIS0.253Inavolisib— uncovered
PANCREAS_BETA_CELLS0.234Cobimetinib— uncovered
UV_RESPONSE_DN0.228Inavolisib— uncovered
REACTIVE_OXYGEN_SPECIES_PATHWAY0.222Inavolisib— uncovered
KRAS_SIGNALING_DN0.220Remibrutinib— uncovered
ADIPOGENESIS0.209Inavolisib— uncovered
OXIDATIVE_PHOSPHORYLATION0.198Remibrutinib— uncovered
FATTY_ACID_METABOLISM0.181Inavolisib— uncovered
ESTROGEN_RESPONSE_EARLY0.178Inavolisib— uncovered
ESTROGEN_RESPONSE_LATE0.156Idelalisib— uncovered
HEME_METABOLISM0.119Temsirolimus— uncovered
XENOBIOTIC_METABOLISM0.115Inavolisib— uncovered
MTORC1_SIGNALING0.112Inavolisib— uncovered
SPERMATOGENESIS0.095Inavolisib— uncovered
PI3K_AKT_MTOR_SIGNALING0.032Inavolisib— uncovered
HEDGEHOG_SIGNALING0.031Inavolisib— uncovered
KRAS_SIGNALING_UP0.025Inavolisib— uncovered