MDT-AP-1143
Med · Medulloblastoma
Clinical attributes
From the source cohort, normalized into canonical keys plus the project's native columns.
- cancer_type
- Med
- cancer_type_detailed
- —
- subtype
- Medulloblastoma
- cancer_type
- Med
- subtype
- Medulloblastoma
- overall_survival_months
- 108.96000000000001
- os_event
- false
- age_years
- 5
- sex
- M
- fusion
- other ZFTA
- new_clusters
- C5
- umap1_2d
- 5.110280586
- umap2_2d
- 4.936567683
- umap1_3d
- -0.02891342
- umap2_3d
- -0.61182806
- umap3_3d
- 0.808996789
- dataset
- Med-Taylor
GSVA pathway preview (0 Hallmark scores)
Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.
Patient twins — nearest pathway neighbors
10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.
5 twins match this tumor's tissue · 5 come from a different tissue of origin ← cross-tissue dominant
| # | Sample | Cancer type | Subtype | cos similarity |
|---|---|---|---|---|
| 1 | SRR1419714 | GTEX | — | 0.967 |
| 2 | MNG436 | — | — | 0.964 |
| 3 | MNG923 | — | — | 0.964 |
| 4 | SRR1348861 | GTEX | — | 0.961 |
| 5 | MNG1118 | — | — | 0.960 |
| 6 | MNG1259 | — | — | 0.960 |
| 7 | SRR1413454 | GTEX | — | 0.960 |
| 8 | SRR1500405 | GTEX | — | 0.958 |
| 9 | SRR1468974 | GTEX | — | 0.953 |
| 10 | MNG1003 | — | — | 0.953 |
Per-pathway drug coverage
For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.
0 of 11 elevated pathways have at least one drug that meaningfully reverses them.
| Pathway (elevated) | tumor score | Best drug | reversal magnitude |
|---|---|---|---|
| KRAS_SIGNALING_DN | 0.410 | Remibrutinib | — uncovered |
| PANCREAS_BETA_CELLS | 0.320 | Cobimetinib | — uncovered |
| APICAL_SURFACE | 0.240 | Temsirolimus | — uncovered |
| SPERMATOGENESIS | 0.220 | Inavolisib | — uncovered |
| ALLOGRAFT_REJECTION | 0.190 | Idelalisib | — uncovered |
| COAGULATION | 0.180 | Binimetinib | — uncovered |
| HEDGEHOG_SIGNALING | 0.130 | Inavolisib | — uncovered |
| KRAS_SIGNALING_UP | 0.110 | Inavolisib | — uncovered |
| ANGIOGENESIS | 0.100 | Remibrutinib | — uncovered |
| MYOGENESIS | 0.070 | Inavolisib | — uncovered |
| INFLAMMATORY_RESPONSE | 0.010 | Idelalisib | — uncovered |